Six adult patients with septo-optic dysplasia and drug-resistant epilepsy: Clinical findings and course

Septo-optic dysplasia (SOD) is a rare disorder associated with optic nerve hypoplasia, pituitary abnormalities and agenesis/dysgenesis of midline brain structures including the septum pellucidum and corpus callosum. Though sometimes associated with drug-resistant epilepsy, this association has not b...

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Main Authors:	Mashael AlKhateeb, Richard McLachlan, Jorge Burneo, David Diosy, Seyed Mirsattari
Format:	Article
Language:	English
Published:	Elsevier 2017-01-01
Series:	Epilepsy and Behavior Case Reports
Subjects:	Septo-optic dysplasia Seizures Epilepsy Drug-resistant Cortical malformation Seizure surgery
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213323216300858

id	doaj-72ad76c2b0174abab4c56f0058d72f29
record_format	Article
spelling	doaj-72ad76c2b0174abab4c56f0058d72f292020-11-24T20:52:27ZengElsevierEpilepsy and Behavior Case Reports2213-32322017-01-018C738410.1016/j.ebcr.2017.04.001Six adult patients with septo-optic dysplasia and drug-resistant epilepsy: Clinical findings and courseMashael AlKhateeb0Richard McLachlan1Jorge Burneo2David Diosy3Seyed Mirsattari4Department of Neuroscience, London health science center, Western University, London, Ontario, CanadaDepartment of Neuroscience, London health science center, Western University, London, Ontario, CanadaDepartment of Neuroscience, London health science center, Western University, London, Ontario, CanadaDepartment of Neuroscience, London health science center, Western University, London, Ontario, CanadaDepartment of Neuroscience, London health science center, Western University, London, Ontario, CanadaSepto-optic dysplasia (SOD) is a rare disorder associated with optic nerve hypoplasia, pituitary abnormalities and agenesis/dysgenesis of midline brain structures including the septum pellucidum and corpus callosum. Though sometimes associated with drug-resistant epilepsy, this association has not been well studied. We report six SOD patients with associated malformation of cortical development (MCD) and drug-resistant epilepsy who underwent video-EEG telemetry at our centre between 1998 and 2016 for drug-resistant epilepsy. ‬Three then underwent surgery; right temporal neocortical resection, right functional hemispherectomy and placement of a vagus nerve stimulator. Clinical findings and the patients' ultimate courses are discussed.http://www.sciencedirect.com/science/article/pii/S2213323216300858Septo-optic dysplasiaSeizuresEpilepsyDrug-resistantCortical malformationSeizure surgery
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mashael AlKhateeb Richard McLachlan Jorge Burneo David Diosy Seyed Mirsattari
spellingShingle	Mashael AlKhateeb Richard McLachlan Jorge Burneo David Diosy Seyed Mirsattari Six adult patients with septo-optic dysplasia and drug-resistant epilepsy: Clinical findings and course Epilepsy and Behavior Case Reports Septo-optic dysplasia Seizures Epilepsy Drug-resistant Cortical malformation Seizure surgery
author_facet	Mashael AlKhateeb Richard McLachlan Jorge Burneo David Diosy Seyed Mirsattari
author_sort	Mashael AlKhateeb
title	Six adult patients with septo-optic dysplasia and drug-resistant epilepsy: Clinical findings and course
title_short	Six adult patients with septo-optic dysplasia and drug-resistant epilepsy: Clinical findings and course
title_full	Six adult patients with septo-optic dysplasia and drug-resistant epilepsy: Clinical findings and course
title_fullStr	Six adult patients with septo-optic dysplasia and drug-resistant epilepsy: Clinical findings and course
title_full_unstemmed	Six adult patients with septo-optic dysplasia and drug-resistant epilepsy: Clinical findings and course
title_sort	six adult patients with septo-optic dysplasia and drug-resistant epilepsy: clinical findings and course
publisher	Elsevier
series	Epilepsy and Behavior Case Reports
issn	2213-3232
publishDate	2017-01-01
description	Septo-optic dysplasia (SOD) is a rare disorder associated with optic nerve hypoplasia, pituitary abnormalities and agenesis/dysgenesis of midline brain structures including the septum pellucidum and corpus callosum. Though sometimes associated with drug-resistant epilepsy, this association has not been well studied. We report six SOD patients with associated malformation of cortical development (MCD) and drug-resistant epilepsy who underwent video-EEG telemetry at our centre between 1998 and 2016 for drug-resistant epilepsy. ‬Three then underwent surgery; right temporal neocortical resection, right functional hemispherectomy and placement of a vagus nerve stimulator. Clinical findings and the patients' ultimate courses are discussed.
topic	Septo-optic dysplasia Seizures Epilepsy Drug-resistant Cortical malformation Seizure surgery
url	http://www.sciencedirect.com/science/article/pii/S2213323216300858
work_keys_str_mv	AT mashaelalkhateeb sixadultpatientswithseptoopticdysplasiaanddrugresistantepilepsyclinicalfindingsandcourse AT richardmclachlan sixadultpatientswithseptoopticdysplasiaanddrugresistantepilepsyclinicalfindingsandcourse AT jorgeburneo sixadultpatientswithseptoopticdysplasiaanddrugresistantepilepsyclinicalfindingsandcourse AT daviddiosy sixadultpatientswithseptoopticdysplasiaanddrugresistantepilepsyclinicalfindingsandcourse AT seyedmirsattari sixadultpatientswithseptoopticdysplasiaanddrugresistantepilepsyclinicalfindingsandcourse
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Six adult patients with septo-optic dysplasia and drug-resistant epilepsy: Clinical findings and course

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