Thrombotic Microangiopathy in a Kidney Transplant Patient With COVID-19

Kidney transplant recipients are at increased risk for infection, including coronavirus disease 2019 (COVID-19), given ongoing immunosuppression. In individuals with COVID-19, complications including thrombosis and endothelial dysfunction portend worse outcomes. In this report, we describe a kidney...

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Main Authors:	Arturo Bascuñana, Antonia Mijaylova, Almudena Vega, Nicolás Macías, Eduardo Verde, Maria Luisa Rodríguez-Ferrero, Andrés Delgado, Javier Carbayo, Marian Goicoechea
Format:	Article
Language:	English
Published:	Elsevier 2021-01-01
Series:	Kidney Medicine
Subjects:	COVID-19 kidney transplant thrombotic microangiopathy acute kidney injury
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590059520302594

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spelling	doaj-72b02c042be24a779e0409f1f83bde4b2021-02-05T15:32:21ZengElsevierKidney Medicine2590-05952021-01-0131124127Thrombotic Microangiopathy in a Kidney Transplant Patient With COVID-19Arturo Bascuñana0Antonia Mijaylova1Almudena Vega2Nicolás Macías3Eduardo Verde4Maria Luisa Rodríguez-Ferrero5Andrés Delgado6Javier Carbayo7Marian Goicoechea8Nephrology Department, Hospital General Universitario Gregorio Marañón, Madrid, SpainNephrology Department, Hospital General Universitario Gregorio Marañón, Madrid, SpainAddress for Correspondence: Almudena Vega, PhD, Nephrology Department, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo, 46, Madrid 28007, Spain; Nephrology Department, Hospital General Universitario Gregorio Marañón, Madrid, SpainNephrology Department, Hospital General Universitario Gregorio Marañón, Madrid, SpainNephrology Department, Hospital General Universitario Gregorio Marañón, Madrid, SpainNephrology Department, Hospital General Universitario Gregorio Marañón, Madrid, SpainNephrology Department, Hospital General Universitario Gregorio Marañón, Madrid, SpainNephrology Department, Hospital General Universitario Gregorio Marañón, Madrid, SpainNephrology Department, Hospital General Universitario Gregorio Marañón, Madrid, SpainKidney transplant recipients are at increased risk for infection, including coronavirus disease 2019 (COVID-19), given ongoing immunosuppression. In individuals with COVID-19, complications including thrombosis and endothelial dysfunction portend worse outcomes. In this report, we describe a kidney transplant recipient who developed severe thrombotic microangiopathy with a low platelet count (12 ×109/L), anemia (hemoglobin, 7.5 g/dL with 7% schistocytes on peripheral-blood smear), and severe acute kidney injury concurrent with COVID-19. The clinical course improved after plasma exchange. Given this presentation, we hypothesize that COVID-19 triggered thrombotic microangiopathy.http://www.sciencedirect.com/science/article/pii/S2590059520302594COVID-19kidney transplantthrombotic microangiopathyacute kidney injury
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Arturo Bascuñana Antonia Mijaylova Almudena Vega Nicolás Macías Eduardo Verde Maria Luisa Rodríguez-Ferrero Andrés Delgado Javier Carbayo Marian Goicoechea
spellingShingle	Arturo Bascuñana Antonia Mijaylova Almudena Vega Nicolás Macías Eduardo Verde Maria Luisa Rodríguez-Ferrero Andrés Delgado Javier Carbayo Marian Goicoechea Thrombotic Microangiopathy in a Kidney Transplant Patient With COVID-19 Kidney Medicine COVID-19 kidney transplant thrombotic microangiopathy acute kidney injury
author_facet	Arturo Bascuñana Antonia Mijaylova Almudena Vega Nicolás Macías Eduardo Verde Maria Luisa Rodríguez-Ferrero Andrés Delgado Javier Carbayo Marian Goicoechea
author_sort	Arturo Bascuñana
title	Thrombotic Microangiopathy in a Kidney Transplant Patient With COVID-19
title_short	Thrombotic Microangiopathy in a Kidney Transplant Patient With COVID-19
title_full	Thrombotic Microangiopathy in a Kidney Transplant Patient With COVID-19
title_fullStr	Thrombotic Microangiopathy in a Kidney Transplant Patient With COVID-19
title_full_unstemmed	Thrombotic Microangiopathy in a Kidney Transplant Patient With COVID-19
title_sort	thrombotic microangiopathy in a kidney transplant patient with covid-19
publisher	Elsevier
series	Kidney Medicine
issn	2590-0595
publishDate	2021-01-01
description	Kidney transplant recipients are at increased risk for infection, including coronavirus disease 2019 (COVID-19), given ongoing immunosuppression. In individuals with COVID-19, complications including thrombosis and endothelial dysfunction portend worse outcomes. In this report, we describe a kidney transplant recipient who developed severe thrombotic microangiopathy with a low platelet count (12 ×109/L), anemia (hemoglobin, 7.5 g/dL with 7% schistocytes on peripheral-blood smear), and severe acute kidney injury concurrent with COVID-19. The clinical course improved after plasma exchange. Given this presentation, we hypothesize that COVID-19 triggered thrombotic microangiopathy.
topic	COVID-19 kidney transplant thrombotic microangiopathy acute kidney injury
url	http://www.sciencedirect.com/science/article/pii/S2590059520302594
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Thrombotic Microangiopathy in a Kidney Transplant Patient With COVID-19

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