Antigenic and genomic relation between human influenza A (H3N2) viruses circulating in Argentina during 1998 and the H3N2 vaccine component
Objective. Due to the lack of correlation from 1994 to 1997 between the A H3N2 component of the influenza vaccine recommended for this period and the circulating viruses in Argentina, we decided to study the antigenic and genomic relationships of the 1998 A H3N2 Argentine circulating strains with th...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Pan American Health Organization
2001-04-01
|
Series: | Revista Panamericana de Salud Pública |
Subjects: | |
Online Access: | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892001000400007&lng=en&tlng=en |
id |
doaj-72b0c013a85f436eadb940f00ccc71b0 |
---|---|
record_format |
Article |
spelling |
doaj-72b0c013a85f436eadb940f00ccc71b02020-11-24T22:04:18ZengPan American Health OrganizationRevista Panamericana de Salud Pública1020-49892001-04-019424625310.1590/s1020-49892001000400007S1020-49892001000400007Antigenic and genomic relation between human influenza A (H3N2) viruses circulating in Argentina during 1998 and the H3N2 vaccine componentAndrea V. Pontoriero0Elsa G. Baumeister1Ana M. Campos2Vilma L. Savy3Yi P. Lin4Alan J. Hay5Instituto Nacional de EnfermedadesInstituto Nacional de EnfermedadesInstituto Nacional de EnfermedadesInstituto Nacional de EnfermedadesNational Institute for Medical ResearchNational Institute for Medical ResearchObjective. Due to the lack of correlation from 1994 to 1997 between the A H3N2 component of the influenza vaccine recommended for this period and the circulating viruses in Argentina, we decided to study the antigenic and genomic relationships of the 1998 A H3N2 Argentine circulating strains with the corresponding vaccine component for that year as recommended by the World Health Organization (WHO). Methods. We selected 18 influenza A H3N2 strains isolated in Argentina during 1998 to carry out an antigenic and genomic study of their hemagglutinin (HA) and neuraminidase (NA) proteins. For the genomic study we added 3 isolates from Uruguay. We compared the Argentine and Uruguayan strains with available reference strains. Results. We found that all 18 strains from Argentina were similar to the A/Sydney/5/97 (H3N2) strain, as opposed to the A/Wuhan/359/95 (H3N2) strain, which was the vaccine component. This result was confirmed by the genomic study. Conclusions. The approach that we applied in Argentina has improved the quality and quantity of information about influenza in the country. This type of work should be encouraged in other countries in order to help choose the most appropriate vaccine components each year and provide individuals with the best possible protection against influenza.http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892001000400007&lng=en&tlng=enInfluenzaimmunizationArgentina |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andrea V. Pontoriero Elsa G. Baumeister Ana M. Campos Vilma L. Savy Yi P. Lin Alan J. Hay |
spellingShingle |
Andrea V. Pontoriero Elsa G. Baumeister Ana M. Campos Vilma L. Savy Yi P. Lin Alan J. Hay Antigenic and genomic relation between human influenza A (H3N2) viruses circulating in Argentina during 1998 and the H3N2 vaccine component Revista Panamericana de Salud Pública Influenza immunization Argentina |
author_facet |
Andrea V. Pontoriero Elsa G. Baumeister Ana M. Campos Vilma L. Savy Yi P. Lin Alan J. Hay |
author_sort |
Andrea V. Pontoriero |
title |
Antigenic and genomic relation between human influenza A (H3N2) viruses circulating in Argentina during 1998 and the H3N2 vaccine component |
title_short |
Antigenic and genomic relation between human influenza A (H3N2) viruses circulating in Argentina during 1998 and the H3N2 vaccine component |
title_full |
Antigenic and genomic relation between human influenza A (H3N2) viruses circulating in Argentina during 1998 and the H3N2 vaccine component |
title_fullStr |
Antigenic and genomic relation between human influenza A (H3N2) viruses circulating in Argentina during 1998 and the H3N2 vaccine component |
title_full_unstemmed |
Antigenic and genomic relation between human influenza A (H3N2) viruses circulating in Argentina during 1998 and the H3N2 vaccine component |
title_sort |
antigenic and genomic relation between human influenza a (h3n2) viruses circulating in argentina during 1998 and the h3n2 vaccine component |
publisher |
Pan American Health Organization |
series |
Revista Panamericana de Salud Pública |
issn |
1020-4989 |
publishDate |
2001-04-01 |
description |
Objective. Due to the lack of correlation from 1994 to 1997 between the A H3N2 component of the influenza vaccine recommended for this period and the circulating viruses in Argentina, we decided to study the antigenic and genomic relationships of the 1998 A H3N2 Argentine circulating strains with the corresponding vaccine component for that year as recommended by the World Health Organization (WHO). Methods. We selected 18 influenza A H3N2 strains isolated in Argentina during 1998 to carry out an antigenic and genomic study of their hemagglutinin (HA) and neuraminidase (NA) proteins. For the genomic study we added 3 isolates from Uruguay. We compared the Argentine and Uruguayan strains with available reference strains. Results. We found that all 18 strains from Argentina were similar to the A/Sydney/5/97 (H3N2) strain, as opposed to the A/Wuhan/359/95 (H3N2) strain, which was the vaccine component. This result was confirmed by the genomic study. Conclusions. The approach that we applied in Argentina has improved the quality and quantity of information about influenza in the country. This type of work should be encouraged in other countries in order to help choose the most appropriate vaccine components each year and provide individuals with the best possible protection against influenza. |
topic |
Influenza immunization Argentina |
url |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892001000400007&lng=en&tlng=en |
work_keys_str_mv |
AT andreavpontoriero antigenicandgenomicrelationbetweenhumaninfluenzaah3n2virusescirculatinginargentinaduring1998andtheh3n2vaccinecomponent AT elsagbaumeister antigenicandgenomicrelationbetweenhumaninfluenzaah3n2virusescirculatinginargentinaduring1998andtheh3n2vaccinecomponent AT anamcampos antigenicandgenomicrelationbetweenhumaninfluenzaah3n2virusescirculatinginargentinaduring1998andtheh3n2vaccinecomponent AT vilmalsavy antigenicandgenomicrelationbetweenhumaninfluenzaah3n2virusescirculatinginargentinaduring1998andtheh3n2vaccinecomponent AT yiplin antigenicandgenomicrelationbetweenhumaninfluenzaah3n2virusescirculatinginargentinaduring1998andtheh3n2vaccinecomponent AT alanjhay antigenicandgenomicrelationbetweenhumaninfluenzaah3n2virusescirculatinginargentinaduring1998andtheh3n2vaccinecomponent |
_version_ |
1725829535135432704 |