Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity
Isolation, finding or discovery of novel anticancer agents is very important for cancer treatment, and seaweeds are one of the largest producers of chemically active metabolites with valuable cytotoxic properties, and therefore can be used as new chemotherapeutic agents or source of inspiration to d...
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doaj-72b76ada15e54b499fd2cc8a50c1aae72020-11-25T02:18:58ZengMDPI AGMarine Drugs1660-33972018-10-01161141010.3390/md16110410md16110410Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer ActivityDjenisa H. A. Rocha0Ana M. L. Seca1Diana C. G. A. Pinto2Department of Chemistry & QOPNA-Organic Chemistry, Natural Products and Food Stuffs, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, PortugalDepartment of Chemistry & QOPNA-Organic Chemistry, Natural Products and Food Stuffs, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, PortugalDepartment of Chemistry & QOPNA-Organic Chemistry, Natural Products and Food Stuffs, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, PortugalIsolation, finding or discovery of novel anticancer agents is very important for cancer treatment, and seaweeds are one of the largest producers of chemically active metabolites with valuable cytotoxic properties, and therefore can be used as new chemotherapeutic agents or source of inspiration to develop new ones. Identification of the more potent and selective anticancer components isolated from brown, green and red seaweeds, as well as studies of their mode of action is very attractive and constitute a small but relevant progress for pharmacological applications. Several researchers have carried out in vitro and in vivo studies in various cell lines and have disclosed the active metabolites among the terpenoids, including carotenoids, polyphenols and alkaloids that can be found in seaweeds. In this review the type of metabolites and their cytotoxic or antiproliferative effects will be discussed additionally their mode of action, structure-activity relationship and selectivity will also be revealed. The diterpene dictyolactone, the sterol cholest-5-en-3β,7α-diol and the halogenated monoterpene halomon are among the reported compounds, the ones that present sub-micromolar cytotoxicity. Additionally, one dimeric sesquiterpene of the cyclolaurane-type, three bromophenols and one halogenated monoterpene should be emphasized because they exhibit half maximal inhibitory concentration (IC<sub>50</sub>) values between 1⁻5 µM against several cell lines.https://www.mdpi.com/1660-3397/16/11/410seaweedssecondary metabolitescytotoxic activitycancerterpenoidsbromophenolsdictyolactonecholest-5-en-3β,7α-diolhalomonlaurebiphenyl |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Djenisa H. A. Rocha Ana M. L. Seca Diana C. G. A. Pinto |
spellingShingle |
Djenisa H. A. Rocha Ana M. L. Seca Diana C. G. A. Pinto Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity Marine Drugs seaweeds secondary metabolites cytotoxic activity cancer terpenoids bromophenols dictyolactone cholest-5-en-3β,7α-diol halomon laurebiphenyl |
author_facet |
Djenisa H. A. Rocha Ana M. L. Seca Diana C. G. A. Pinto |
author_sort |
Djenisa H. A. Rocha |
title |
Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity |
title_short |
Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity |
title_full |
Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity |
title_fullStr |
Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity |
title_full_unstemmed |
Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity |
title_sort |
seaweed secondary metabolites in vitro and in vivo anticancer activity |
publisher |
MDPI AG |
series |
Marine Drugs |
issn |
1660-3397 |
publishDate |
2018-10-01 |
description |
Isolation, finding or discovery of novel anticancer agents is very important for cancer treatment, and seaweeds are one of the largest producers of chemically active metabolites with valuable cytotoxic properties, and therefore can be used as new chemotherapeutic agents or source of inspiration to develop new ones. Identification of the more potent and selective anticancer components isolated from brown, green and red seaweeds, as well as studies of their mode of action is very attractive and constitute a small but relevant progress for pharmacological applications. Several researchers have carried out in vitro and in vivo studies in various cell lines and have disclosed the active metabolites among the terpenoids, including carotenoids, polyphenols and alkaloids that can be found in seaweeds. In this review the type of metabolites and their cytotoxic or antiproliferative effects will be discussed additionally their mode of action, structure-activity relationship and selectivity will also be revealed. The diterpene dictyolactone, the sterol cholest-5-en-3β,7α-diol and the halogenated monoterpene halomon are among the reported compounds, the ones that present sub-micromolar cytotoxicity. Additionally, one dimeric sesquiterpene of the cyclolaurane-type, three bromophenols and one halogenated monoterpene should be emphasized because they exhibit half maximal inhibitory concentration (IC<sub>50</sub>) values between 1⁻5 µM against several cell lines. |
topic |
seaweeds secondary metabolites cytotoxic activity cancer terpenoids bromophenols dictyolactone cholest-5-en-3β,7α-diol halomon laurebiphenyl |
url |
https://www.mdpi.com/1660-3397/16/11/410 |
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