Drep-2 is a novel synaptic protein important for learning and memory
CIDE-N domains mediate interactions between the DNase Dff40/CAD and its inhibitor Dff45/ICAD. In this study, we report that the CIDE-N protein Drep-2 is a novel synaptic protein important for learning and behavioral adaptation. Drep-2 was found at synapses throughout the Drosophila brain and was str...
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eLife Sciences Publications Ltd
2014-11-01
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| Online Access: | https://elifesciences.org/articles/03895 |
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doaj-72baee70ec5a4bf5abbdb58a4e75f68d2021-05-04T23:31:33ZengeLife Sciences Publications LtdeLife2050-084X2014-11-01310.7554/eLife.03895Drep-2 is a novel synaptic protein important for learning and memoryTill F M Andlauer0https://orcid.org/0000-0002-2917-5889Sabrina Scholz-Kornehl1Rui Tian2Marieluise Kirchner3Husam A Babikir4Harald Depner5Bernhard Loll6Christine Quentin7Varun K Gupta8Matthew G Holt9Shubham Dipt10Michael Cressy11Markus C Wahl12André Fiala13Matthias Selbach14Martin Schwärzel15Stephan J Sigrist16Genetics, Institute of Biology, Freie Universität Berlin, Berlin, Germany; Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, Julius-Maximilians-Universität Würzburg, Würzburg, Germany; Max Planck Institute of Colloids and Interfaces, Potsdam, GermanyGenetics, Institute of Biology, Freie Universität Berlin, Berlin, GermanyGenetics, Institute of Biology, Freie Universität Berlin, Berlin, Germany; Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, Julius-Maximilians-Universität Würzburg, Würzburg, GermanyDepartment of Cell Signalling and Mass Spectrometry, Max-Delbrück-Centrum für Molekulare Medizin, Berlin-Buch, GermanyGenetics, Institute of Biology, Freie Universität Berlin, Berlin, GermanyGenetics, Institute of Biology, Freie Universität Berlin, Berlin, GermanyInstitute of Chemistry and Biochemisty, Freie Universität Berlin, Berlin, GermanyGenetics, Institute of Biology, Freie Universität Berlin, Berlin, GermanyGenetics, Institute of Biology, Freie Universität Berlin, Berlin, GermanyDepartment Laboratory of Glia Biology, Vlaams Instituut voor Biotechnologie (VIB) Center for the Biology of Disease, Katholieke Universiteit Leuven, Leuven, BelgiumDepartment of Molecular Neurobiology of Behavior, Georg-August-Universität Göttingen, Göttingen, GermanyDepartment of Neuroscience, Cold Spring Harbor Laboratory, Cold Spring Harbor, United StatesInstitute of Chemistry and Biochemisty, Freie Universität Berlin, Berlin, GermanyDepartment of Molecular Neurobiology of Behavior, Georg-August-Universität Göttingen, Göttingen, GermanyDepartment of Cell Signalling and Mass Spectrometry, Max-Delbrück-Centrum für Molekulare Medizin, Berlin-Buch, GermanyGenetics, Institute of Biology, Freie Universität Berlin, Berlin, GermanyGenetics, Institute of Biology, Freie Universität Berlin, Berlin, Germany; NeuroCure Cluster of Excellence, Charité Universitätsmedizin Berlin, Berlin, GermanyCIDE-N domains mediate interactions between the DNase Dff40/CAD and its inhibitor Dff45/ICAD. In this study, we report that the CIDE-N protein Drep-2 is a novel synaptic protein important for learning and behavioral adaptation. Drep-2 was found at synapses throughout the Drosophila brain and was strongly enriched at mushroom body input synapses. It was required within Kenyon cells for normal olfactory short- and intermediate-term memory. Drep-2 colocalized with metabotropic glutamate receptors (mGluRs). Chronic pharmacological stimulation of mGluRs compensated for drep-2 learning deficits, and drep-2 and mGluR learning phenotypes behaved non-additively, suggesting that Drep 2 might be involved in effective mGluR signaling. In fact, Drosophila fragile X protein mutants, shown to benefit from attenuation of mGluR signaling, profited from the elimination of drep-2. Thus, Drep-2 is a novel regulatory synaptic factor, probably intersecting with metabotropic signaling and translational regulation.https://elifesciences.org/articles/03895synapselearning and memorymushroom bodymetabotropic glutamate receptorfragile X syndromeCIDE-N protein family |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Till F M Andlauer Sabrina Scholz-Kornehl Rui Tian Marieluise Kirchner Husam A Babikir Harald Depner Bernhard Loll Christine Quentin Varun K Gupta Matthew G Holt Shubham Dipt Michael Cressy Markus C Wahl André Fiala Matthias Selbach Martin Schwärzel Stephan J Sigrist |
| spellingShingle |
Till F M Andlauer Sabrina Scholz-Kornehl Rui Tian Marieluise Kirchner Husam A Babikir Harald Depner Bernhard Loll Christine Quentin Varun K Gupta Matthew G Holt Shubham Dipt Michael Cressy Markus C Wahl André Fiala Matthias Selbach Martin Schwärzel Stephan J Sigrist Drep-2 is a novel synaptic protein important for learning and memory eLife synapse learning and memory mushroom body metabotropic glutamate receptor fragile X syndrome CIDE-N protein family |
| author_facet |
Till F M Andlauer Sabrina Scholz-Kornehl Rui Tian Marieluise Kirchner Husam A Babikir Harald Depner Bernhard Loll Christine Quentin Varun K Gupta Matthew G Holt Shubham Dipt Michael Cressy Markus C Wahl André Fiala Matthias Selbach Martin Schwärzel Stephan J Sigrist |
| author_sort |
Till F M Andlauer |
| title |
Drep-2 is a novel synaptic protein important for learning and memory |
| title_short |
Drep-2 is a novel synaptic protein important for learning and memory |
| title_full |
Drep-2 is a novel synaptic protein important for learning and memory |
| title_fullStr |
Drep-2 is a novel synaptic protein important for learning and memory |
| title_full_unstemmed |
Drep-2 is a novel synaptic protein important for learning and memory |
| title_sort |
drep-2 is a novel synaptic protein important for learning and memory |
| publisher |
eLife Sciences Publications Ltd |
| series |
eLife |
| issn |
2050-084X |
| publishDate |
2014-11-01 |
| description |
CIDE-N domains mediate interactions between the DNase Dff40/CAD and its inhibitor Dff45/ICAD. In this study, we report that the CIDE-N protein Drep-2 is a novel synaptic protein important for learning and behavioral adaptation. Drep-2 was found at synapses throughout the Drosophila brain and was strongly enriched at mushroom body input synapses. It was required within Kenyon cells for normal olfactory short- and intermediate-term memory. Drep-2 colocalized with metabotropic glutamate receptors (mGluRs). Chronic pharmacological stimulation of mGluRs compensated for drep-2 learning deficits, and drep-2 and mGluR learning phenotypes behaved non-additively, suggesting that Drep 2 might be involved in effective mGluR signaling. In fact, Drosophila fragile X protein mutants, shown to benefit from attenuation of mGluR signaling, profited from the elimination of drep-2. Thus, Drep-2 is a novel regulatory synaptic factor, probably intersecting with metabotropic signaling and translational regulation. |
| topic |
synapse learning and memory mushroom body metabotropic glutamate receptor fragile X syndrome CIDE-N protein family |
| url |
https://elifesciences.org/articles/03895 |
| work_keys_str_mv |
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