Successful therapy for enteropathy-associated peripheral T-cell lymphoma using high-dose polychemotherapy and autologous hematopoietic stem cell transplantation

• Main Authors: V I Vorob'ev, S K Kravchenko, A M Kovrigina
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2013-07-01
• Series: Терапевтический архив
• Subjects: enteropathy-associated t-cell lymphoma; celiac disease; nhl-bfm-90; autologous hematopoietic stem cell transplantation
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/31328

Enteropathy-associated T-cell lymphoma (EATL) is a rare disease that accounts for not more than 1.4% of all lymphomas. It is most common in Europe, followed by North America and Asia. The disease is associated with gluten-sensitive celiac disease in 50% of cases and divided into types I and II. Mean-dose CHOP-like therapy is ineffective, with a median overall survival of 7-10 months. With high-dose therapy, 5-year survival rates can be 60%, but it can be used in not more than half of the cases. This is associated with the serious somatic status of most patients at diagnosis and with a median age of 57-64 years. The article presents a literature review and a case of successful therapy in a 58-year-old patient with type I EATL using the mNHL-BFM-90 protocol and autologous hematopoietic stem cell transplantation.