Combined high expression of CD47 and CD68 is a novel prognostic factor for breast cancer patients
Abstract Background Avoiding the phagocytosis by tumor-associated macrophages (TAMs) is necessary for the growth and metastasis of solid tumors. CD47 binds to the receptor signal-regulatory protein-α (SIRP-α) on the macrophages to avoid normal phagocytosis. In this study, we evaluated the expression...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2019-09-01
|
Series: | Cancer Cell International |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12935-019-0957-0 |
id |
doaj-72c8bc0311ee418482953fa9a1d08073 |
---|---|
record_format |
Article |
spelling |
doaj-72c8bc0311ee418482953fa9a1d080732020-11-25T02:41:53ZengBMCCancer Cell International1475-28672019-09-0119111210.1186/s12935-019-0957-0Combined high expression of CD47 and CD68 is a novel prognostic factor for breast cancer patientsJingping Yuan0Huihua He1Chuang Chen2Juan Wu3Jie Rao4Honglin Yan5Department of Pathology, Renmin Hospital of Wuhan UniversityDepartment of Pathology, Renmin Hospital of Wuhan UniversityDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan UniversityDepartment of Pathology, Renmin Hospital of Wuhan UniversityDepartment of Pathology, Renmin Hospital of Wuhan UniversityDepartment of Pathology, Renmin Hospital of Wuhan UniversityAbstract Background Avoiding the phagocytosis by tumor-associated macrophages (TAMs) is necessary for the growth and metastasis of solid tumors. CD47 binds to the receptor signal-regulatory protein-α (SIRP-α) on the macrophages to avoid normal phagocytosis. In this study, we evaluated the expression and prognostic significance of CD47 and CD68-labeled TAMs in breast cancer solid tumors. Methods Two hundred seventeen cases of breast cancer tissues and 40 cases of benign breast lesions were collected for immunohistochemical staining of CD47 and CD68. Results Both of the CD47 and CD68 expression were significantly higher in breast cancer tissues (P < 0.001), and associated with multiple clinicopathological parameters in breast cancer (P < 0.05). However, CD47 or CD68 expression alone was not an independent predictor of poor DFS in multivariate survival analysis (P > 0.05). Interestingly, combined high expression of CD47 and CD68 (CD47highCD68high) not only had a significant association with advanced TNM stage, histological grade, LNM, ER status, PR status and recurrence (P < 0.05), but also displayed a poorer 5-DFS (P = 0.011). Strikingly, CD47highCD68high served as a novel independent prognostic factor for poor DFS compared to the expression of CD47 or CD68 alone (P = 0.045). Furthermore, our study also showed for the first time that the prognostic significance of CD47highCD68high not only in breast cancer in general, but also in hormone receptor-negative breast cancer in particular. Conclusions Combined detection of CD47 and CD68 may provide guidance for the prognosis of breast cancer, especially hormone receptor-negative breast cancer.http://link.springer.com/article/10.1186/s12935-019-0957-0Breast cancerHormone receptor-negative breast cancerCD47CD68 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jingping Yuan Huihua He Chuang Chen Juan Wu Jie Rao Honglin Yan |
spellingShingle |
Jingping Yuan Huihua He Chuang Chen Juan Wu Jie Rao Honglin Yan Combined high expression of CD47 and CD68 is a novel prognostic factor for breast cancer patients Cancer Cell International Breast cancer Hormone receptor-negative breast cancer CD47 CD68 |
author_facet |
Jingping Yuan Huihua He Chuang Chen Juan Wu Jie Rao Honglin Yan |
author_sort |
Jingping Yuan |
title |
Combined high expression of CD47 and CD68 is a novel prognostic factor for breast cancer patients |
title_short |
Combined high expression of CD47 and CD68 is a novel prognostic factor for breast cancer patients |
title_full |
Combined high expression of CD47 and CD68 is a novel prognostic factor for breast cancer patients |
title_fullStr |
Combined high expression of CD47 and CD68 is a novel prognostic factor for breast cancer patients |
title_full_unstemmed |
Combined high expression of CD47 and CD68 is a novel prognostic factor for breast cancer patients |
title_sort |
combined high expression of cd47 and cd68 is a novel prognostic factor for breast cancer patients |
publisher |
BMC |
series |
Cancer Cell International |
issn |
1475-2867 |
publishDate |
2019-09-01 |
description |
Abstract Background Avoiding the phagocytosis by tumor-associated macrophages (TAMs) is necessary for the growth and metastasis of solid tumors. CD47 binds to the receptor signal-regulatory protein-α (SIRP-α) on the macrophages to avoid normal phagocytosis. In this study, we evaluated the expression and prognostic significance of CD47 and CD68-labeled TAMs in breast cancer solid tumors. Methods Two hundred seventeen cases of breast cancer tissues and 40 cases of benign breast lesions were collected for immunohistochemical staining of CD47 and CD68. Results Both of the CD47 and CD68 expression were significantly higher in breast cancer tissues (P < 0.001), and associated with multiple clinicopathological parameters in breast cancer (P < 0.05). However, CD47 or CD68 expression alone was not an independent predictor of poor DFS in multivariate survival analysis (P > 0.05). Interestingly, combined high expression of CD47 and CD68 (CD47highCD68high) not only had a significant association with advanced TNM stage, histological grade, LNM, ER status, PR status and recurrence (P < 0.05), but also displayed a poorer 5-DFS (P = 0.011). Strikingly, CD47highCD68high served as a novel independent prognostic factor for poor DFS compared to the expression of CD47 or CD68 alone (P = 0.045). Furthermore, our study also showed for the first time that the prognostic significance of CD47highCD68high not only in breast cancer in general, but also in hormone receptor-negative breast cancer in particular. Conclusions Combined detection of CD47 and CD68 may provide guidance for the prognosis of breast cancer, especially hormone receptor-negative breast cancer. |
topic |
Breast cancer Hormone receptor-negative breast cancer CD47 CD68 |
url |
http://link.springer.com/article/10.1186/s12935-019-0957-0 |
work_keys_str_mv |
AT jingpingyuan combinedhighexpressionofcd47andcd68isanovelprognosticfactorforbreastcancerpatients AT huihuahe combinedhighexpressionofcd47andcd68isanovelprognosticfactorforbreastcancerpatients AT chuangchen combinedhighexpressionofcd47andcd68isanovelprognosticfactorforbreastcancerpatients AT juanwu combinedhighexpressionofcd47andcd68isanovelprognosticfactorforbreastcancerpatients AT jierao combinedhighexpressionofcd47andcd68isanovelprognosticfactorforbreastcancerpatients AT honglinyan combinedhighexpressionofcd47andcd68isanovelprognosticfactorforbreastcancerpatients |
_version_ |
1724776645033721856 |