Soft surfaces promote astrocytic differentiation of mouse embryonic neural stem cells via dephosphorylation of MRLC in the absence of serum
Abstract Astrocytes, which can be obtained from neural stem cells (NSCs) by adding serum and/or recombinant proteins in culture media or by passaging NSCs repeatedly, are expected to be applicable in regenerative medicine for the treatment of neurodegenerative diseases. However, astrocytes obtained...
Main Authors: | Hiroshi Oyama, Akihiro Nukuda, Seiichiro Ishihara, Hisashi Haga |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-10-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-021-99059-5 |
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