Composite lymphoma of T-cell rich, histiocyte-rich diffuse large B-cell lymphoma and nodular lymphocyte predominant Hodgkin lymphoma: a case report
Abstract Background Composite lymphoma is a rare entity where two or more distinct subtypes of lymphoma coexist within a single organ or tissue. Case presentation We report a new case of a 67-year-old Caucasian male patient, who presented with fatigue, weakness, weight loss, and polyuria. He also ha...
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doaj-72d01ca0f7ef41828382f6606ea2f8b92021-04-18T11:17:41ZengBMCJournal of Medical Case Reports1752-19472021-04-011511610.1186/s13256-021-02783-9Composite lymphoma of T-cell rich, histiocyte-rich diffuse large B-cell lymphoma and nodular lymphocyte predominant Hodgkin lymphoma: a case reportAsil Esper0Sami Alhoulaiby1Ruba Zuhri Yafi2Zuheir Alshehabi3Neurology department, Tishreen University hospitalFaculty of Medicine, Damascus UniversityFaculty of Medicine, Damascus UniversityPathology department, Tishreen University hospitalAbstract Background Composite lymphoma is a rare entity where two or more distinct subtypes of lymphoma coexist within a single organ or tissue. Case presentation We report a new case of a 67-year-old Caucasian male patient, who presented with fatigue, weakness, weight loss, and polyuria. He also had epigastric and left lumbar pain, enlarged spleen, and enlarged left axillary lymph node on examination, with no relevant medical or familial history. A biopsy from the node showed an appearance of T-cell rich, histiocyte-rich diffuse large B-cell lymphoma and nodular lymphocyte predominant Hodgkin lymphoma. The patient was initially treated with adriamycin (doxorubicin), bleomycin, vinblastine, dacarbazine chemotherapy regimen, then switched to rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone regimen. During the therapy, some regression was noticed, especially in the size of the splenic enlargement; however, the patient died 2 months after completing the regimen. Conclusion Composite lymphomas should continue to be studied. Also, treatment is still debatable in type, efficacy, and outcomes.https://doi.org/10.1186/s13256-021-02783-9Composite lymphomaHodgkin lymphomaDiffuse large B-cell lymphomaT-cell lymphoma |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Asil Esper Sami Alhoulaiby Ruba Zuhri Yafi Zuheir Alshehabi |
spellingShingle |
Asil Esper Sami Alhoulaiby Ruba Zuhri Yafi Zuheir Alshehabi Composite lymphoma of T-cell rich, histiocyte-rich diffuse large B-cell lymphoma and nodular lymphocyte predominant Hodgkin lymphoma: a case report Journal of Medical Case Reports Composite lymphoma Hodgkin lymphoma Diffuse large B-cell lymphoma T-cell lymphoma |
author_facet |
Asil Esper Sami Alhoulaiby Ruba Zuhri Yafi Zuheir Alshehabi |
author_sort |
Asil Esper |
title |
Composite lymphoma of T-cell rich, histiocyte-rich diffuse large B-cell lymphoma and nodular lymphocyte predominant Hodgkin lymphoma: a case report |
title_short |
Composite lymphoma of T-cell rich, histiocyte-rich diffuse large B-cell lymphoma and nodular lymphocyte predominant Hodgkin lymphoma: a case report |
title_full |
Composite lymphoma of T-cell rich, histiocyte-rich diffuse large B-cell lymphoma and nodular lymphocyte predominant Hodgkin lymphoma: a case report |
title_fullStr |
Composite lymphoma of T-cell rich, histiocyte-rich diffuse large B-cell lymphoma and nodular lymphocyte predominant Hodgkin lymphoma: a case report |
title_full_unstemmed |
Composite lymphoma of T-cell rich, histiocyte-rich diffuse large B-cell lymphoma and nodular lymphocyte predominant Hodgkin lymphoma: a case report |
title_sort |
composite lymphoma of t-cell rich, histiocyte-rich diffuse large b-cell lymphoma and nodular lymphocyte predominant hodgkin lymphoma: a case report |
publisher |
BMC |
series |
Journal of Medical Case Reports |
issn |
1752-1947 |
publishDate |
2021-04-01 |
description |
Abstract Background Composite lymphoma is a rare entity where two or more distinct subtypes of lymphoma coexist within a single organ or tissue. Case presentation We report a new case of a 67-year-old Caucasian male patient, who presented with fatigue, weakness, weight loss, and polyuria. He also had epigastric and left lumbar pain, enlarged spleen, and enlarged left axillary lymph node on examination, with no relevant medical or familial history. A biopsy from the node showed an appearance of T-cell rich, histiocyte-rich diffuse large B-cell lymphoma and nodular lymphocyte predominant Hodgkin lymphoma. The patient was initially treated with adriamycin (doxorubicin), bleomycin, vinblastine, dacarbazine chemotherapy regimen, then switched to rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone regimen. During the therapy, some regression was noticed, especially in the size of the splenic enlargement; however, the patient died 2 months after completing the regimen. Conclusion Composite lymphomas should continue to be studied. Also, treatment is still debatable in type, efficacy, and outcomes. |
topic |
Composite lymphoma Hodgkin lymphoma Diffuse large B-cell lymphoma T-cell lymphoma |
url |
https://doi.org/10.1186/s13256-021-02783-9 |
work_keys_str_mv |
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