Effect of Korean Red Ginseng supplementation on dry eye syndrome in glaucoma patients – A randomized, double-blind, placebo-controlled study

Background: Many patients with glaucoma have difficulty using antiglaucoma eye drops because of dry eye symptom. In this prospective, randomized, double-blind, placebo-controlled study, we evaluated the effect of Korean Red Ginseng on dry eye syndrome in patients with glaucoma treated with antiglauc...

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Main Authors:	Hyoung Won Bae, Ji Hyun Kim, Sangah Kim, Minkyo Kim, Naeun Lee, Samin Hong, Gong Je Seong, Chan Yun Kim
Format:	Article
Language:	English
Published:	Elsevier 2015-01-01
Series:	Journal of Ginseng Research
Subjects:	dry eye syndrome glaucoma Korean Red Ginseng Panax ginseng
Online Access:	http://www.sciencedirect.com/science/article/pii/S1226845314000852

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spelling	doaj-72d19f8950c84b4db56df37274e61c5c2020-11-24T20:47:03ZengElsevierJournal of Ginseng Research1226-84532015-01-0139171310.1016/j.jgr.2014.07.002Effect of Korean Red Ginseng supplementation on dry eye syndrome in glaucoma patients – A randomized, double-blind, placebo-controlled studyHyoung Won Bae0Ji Hyun Kim1Sangah Kim2Minkyo Kim3Naeun Lee4Samin Hong5Gong Je Seong6Chan Yun Kim7Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, KoreaSiloam Eye Hospital, Seoul, KoreaDepartment of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, KoreaDepartment of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, KoreaDepartment of Ophthalmology, Hallym Hospital, Incheon, KoreaDepartment of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, KoreaDepartment of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, KoreaDepartment of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, KoreaBackground: Many patients with glaucoma have difficulty using antiglaucoma eye drops because of dry eye symptom. In this prospective, randomized, double-blind, placebo-controlled study, we evaluated the effect of Korean Red Ginseng on dry eye syndrome in patients with glaucoma treated with antiglaucoma eye drops. Methods: Forty-nine participants were allocated to the Korean Red Ginseng (3 g/day; n = 24) or placebo (n = 25) groups for 8 weeks. Tear film stability, fluorescein corneal staining, conjunctival hyperemia, tear production, grade of meibomian gland dysfunction, and dry eye questionnaire (Ocular Surface Disease Index) were evaluated at baseline and on completion of the treatment. Results: Almost all patients displayed dry eye symptoms and signs at baseline. After the 8-week intervention, Korean Red Ginseng supplementation significantly improved the tear film stability and total Ocular Surface Disease Index score, as compared to placebo (p < 0.01). Conclusion: Korean Red Ginseng supplementation may provide an additional treatment option for dry eye and patients with glaucoma using antiglaucoma eye drops.http://www.sciencedirect.com/science/article/pii/S1226845314000852dry eye syndromeglaucomaKorean Red GinsengPanax ginseng
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hyoung Won Bae Ji Hyun Kim Sangah Kim Minkyo Kim Naeun Lee Samin Hong Gong Je Seong Chan Yun Kim
spellingShingle	Hyoung Won Bae Ji Hyun Kim Sangah Kim Minkyo Kim Naeun Lee Samin Hong Gong Je Seong Chan Yun Kim Effect of Korean Red Ginseng supplementation on dry eye syndrome in glaucoma patients – A randomized, double-blind, placebo-controlled study Journal of Ginseng Research dry eye syndrome glaucoma Korean Red Ginseng Panax ginseng
author_facet	Hyoung Won Bae Ji Hyun Kim Sangah Kim Minkyo Kim Naeun Lee Samin Hong Gong Je Seong Chan Yun Kim
author_sort	Hyoung Won Bae
title	Effect of Korean Red Ginseng supplementation on dry eye syndrome in glaucoma patients – A randomized, double-blind, placebo-controlled study
title_short	Effect of Korean Red Ginseng supplementation on dry eye syndrome in glaucoma patients – A randomized, double-blind, placebo-controlled study
title_full	Effect of Korean Red Ginseng supplementation on dry eye syndrome in glaucoma patients – A randomized, double-blind, placebo-controlled study
title_fullStr	Effect of Korean Red Ginseng supplementation on dry eye syndrome in glaucoma patients – A randomized, double-blind, placebo-controlled study
title_full_unstemmed	Effect of Korean Red Ginseng supplementation on dry eye syndrome in glaucoma patients – A randomized, double-blind, placebo-controlled study
title_sort	effect of korean red ginseng supplementation on dry eye syndrome in glaucoma patients – a randomized, double-blind, placebo-controlled study
publisher	Elsevier
series	Journal of Ginseng Research
issn	1226-8453
publishDate	2015-01-01
description	Background: Many patients with glaucoma have difficulty using antiglaucoma eye drops because of dry eye symptom. In this prospective, randomized, double-blind, placebo-controlled study, we evaluated the effect of Korean Red Ginseng on dry eye syndrome in patients with glaucoma treated with antiglaucoma eye drops. Methods: Forty-nine participants were allocated to the Korean Red Ginseng (3 g/day; n = 24) or placebo (n = 25) groups for 8 weeks. Tear film stability, fluorescein corneal staining, conjunctival hyperemia, tear production, grade of meibomian gland dysfunction, and dry eye questionnaire (Ocular Surface Disease Index) were evaluated at baseline and on completion of the treatment. Results: Almost all patients displayed dry eye symptoms and signs at baseline. After the 8-week intervention, Korean Red Ginseng supplementation significantly improved the tear film stability and total Ocular Surface Disease Index score, as compared to placebo (p < 0.01). Conclusion: Korean Red Ginseng supplementation may provide an additional treatment option for dry eye and patients with glaucoma using antiglaucoma eye drops.
topic	dry eye syndrome glaucoma Korean Red Ginseng Panax ginseng
url	http://www.sciencedirect.com/science/article/pii/S1226845314000852
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Effect of Korean Red Ginseng supplementation on dry eye syndrome in glaucoma patients – A randomized, double-blind, placebo-controlled study

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