The Role of Non-Coding RNAs in Uveal Melanoma
Uveal melanoma (UM) is the most common primary intraocular tumor in adulthood. Approximately 50% of patients develop metastatic disease, which typically affects the liver and is usually fatal within one year. This type of cancer is heterogeneous in nature and is divided into two broad groups of tumo...
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doaj-72db1e402ea14194879e7d1cc8ef98d62020-11-25T03:52:16ZengMDPI AGCancers2072-66942020-10-01122944294410.3390/cancers12102944The Role of Non-Coding RNAs in Uveal MelanomaManuel Bande0Daniel Fernandez-Diaz1Beatriz Fernandez-Marta2Cristina Rodriguez-Vidal3Nerea Lago-Baameiro4Paula Silva-Rodríguez5Laura Paniagua6María José Blanco-Teijeiro7María Pardo8Antonio Piñeiro9Department of Ophthalmology, University Hospital of Santiago de Compostela, Ramon Baltar S/N, 15706 Santiago de Compostela, SpainDepartment of Ophthalmology, University Hospital of Santiago de Compostela, Ramon Baltar S/N, 15706 Santiago de Compostela, SpainDepartment of Ophthalmology, University Hospital of Santiago de Compostela, Ramon Baltar S/N, 15706 Santiago de Compostela, SpainDepartment of Ophthalmology, University Hospital of Cruces, Cruces Plaza, S/N, 48903 Barakaldo, Vizcaya, SpainGrupo Obesidómica, Instituto de Investigación Sanitaria de Santiago (IDIS), 15706 Santiago de Compostela, SpainTumores Intraoculares en el Adulto, Instituto de Investigación Sanitaria de Santiago (IDIS), 15706 Santiago de Compostela, SpainDepartment of Ophthalmology, University Hospital of Coruña, Praza Parrote, S/N, 15006 La Coruña, SpainDepartment of Ophthalmology, University Hospital of Santiago de Compostela, Ramon Baltar S/N, 15706 Santiago de Compostela, SpainTumores Intraoculares en el Adulto, Instituto de Investigación Sanitaria de Santiago (IDIS), 15706 Santiago de Compostela, SpainDepartment of Ophthalmology, University Hospital of Santiago de Compostela, Ramon Baltar S/N, 15706 Santiago de Compostela, SpainUveal melanoma (UM) is the most common primary intraocular tumor in adulthood. Approximately 50% of patients develop metastatic disease, which typically affects the liver and is usually fatal within one year. This type of cancer is heterogeneous in nature and is divided into two broad groups of tumors according to their susceptibility to develop metastasis. In the last decade, chromosomal abnormalities and the aberrant expression of several signaling pathways and oncogenes in uveal melanomas have been described. Recently, importance has been given to the association of the mentioned deregulation with the expression of non-coding RNAs (ncRNAs). Here, we review the different classes of ncRNAs—such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs)—and their contribution to the development of UM. Special attention is given to miRNAs and their regulatory role in physiopathology and their potential as biomarkers. As important agents in gene regulation, ncRNAs have a huge potential for opening up therapeutic pathways, predicting response to treatment, and anticipating patient outcome for UM.https://www.mdpi.com/2072-6694/12/10/2944uveal melanomancRNAsmiRNAlncRNAsreview |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Manuel Bande Daniel Fernandez-Diaz Beatriz Fernandez-Marta Cristina Rodriguez-Vidal Nerea Lago-Baameiro Paula Silva-Rodríguez Laura Paniagua María José Blanco-Teijeiro María Pardo Antonio Piñeiro |
spellingShingle |
Manuel Bande Daniel Fernandez-Diaz Beatriz Fernandez-Marta Cristina Rodriguez-Vidal Nerea Lago-Baameiro Paula Silva-Rodríguez Laura Paniagua María José Blanco-Teijeiro María Pardo Antonio Piñeiro The Role of Non-Coding RNAs in Uveal Melanoma Cancers uveal melanoma ncRNAs miRNA lncRNAs review |
author_facet |
Manuel Bande Daniel Fernandez-Diaz Beatriz Fernandez-Marta Cristina Rodriguez-Vidal Nerea Lago-Baameiro Paula Silva-Rodríguez Laura Paniagua María José Blanco-Teijeiro María Pardo Antonio Piñeiro |
author_sort |
Manuel Bande |
title |
The Role of Non-Coding RNAs in Uveal Melanoma |
title_short |
The Role of Non-Coding RNAs in Uveal Melanoma |
title_full |
The Role of Non-Coding RNAs in Uveal Melanoma |
title_fullStr |
The Role of Non-Coding RNAs in Uveal Melanoma |
title_full_unstemmed |
The Role of Non-Coding RNAs in Uveal Melanoma |
title_sort |
role of non-coding rnas in uveal melanoma |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2020-10-01 |
description |
Uveal melanoma (UM) is the most common primary intraocular tumor in adulthood. Approximately 50% of patients develop metastatic disease, which typically affects the liver and is usually fatal within one year. This type of cancer is heterogeneous in nature and is divided into two broad groups of tumors according to their susceptibility to develop metastasis. In the last decade, chromosomal abnormalities and the aberrant expression of several signaling pathways and oncogenes in uveal melanomas have been described. Recently, importance has been given to the association of the mentioned deregulation with the expression of non-coding RNAs (ncRNAs). Here, we review the different classes of ncRNAs—such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs)—and their contribution to the development of UM. Special attention is given to miRNAs and their regulatory role in physiopathology and their potential as biomarkers. As important agents in gene regulation, ncRNAs have a huge potential for opening up therapeutic pathways, predicting response to treatment, and anticipating patient outcome for UM. |
topic |
uveal melanoma ncRNAs miRNA lncRNAs review |
url |
https://www.mdpi.com/2072-6694/12/10/2944 |
work_keys_str_mv |
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