Application of therapeutic plasma exchange in patients having severe fever with thrombocytopenia syndrome
Background/Aims Severe fever with thrombocytopenia syndrome (SFTS) is a viral hemorrhagic fever with a high fatality rate. However, effective treatments for SFTS cases not responded to supportive therapy have not been established. Herein, we introduced the therapeutic plasma exchange (TPE) in SFTS p...
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doaj-72dbac3e3d5a4600b4d347275034adf32021-08-10T01:10:39ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482019-07-0134490290910.3904/kjim.2016.194169942Application of therapeutic plasma exchange in patients having severe fever with thrombocytopenia syndromeJeong Rae Yoo0Sun Hyung Kim1Young Ree Kim2Keun Hwa Lee3Won Sup Oh4Sang Taek Heo5 Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea Department of Laboratory Medicine, Jeju National University School of Medicine, Jeju, Korea Department of Laboratory Medicine, Jeju National University School of Medicine, Jeju, Korea Department of Microbiology and Immunology, Jeju National University School of Medicine, Jeju, Korea Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea Department of Internal Medicine, Jeju National University School of Medicine, Jeju, KoreaBackground/Aims Severe fever with thrombocytopenia syndrome (SFTS) is a viral hemorrhagic fever with a high fatality rate. However, effective treatments for SFTS cases not responded to supportive therapy have not been established. Herein, we introduced the therapeutic plasma exchange (TPE) in SFTS patients in a tertiary hospital between 2013 and 2015. Methods TPE was performed in patients with rapidly progressing SFTS. Clinical, laboratory, and virological parameters were compared before and after TPE. Results Among 27 confirmed SFTS patients, two patients were treated with TPE and ribavirin combination in May 2013, then, 14 patients with rapidly progressing SFTS patients were treated with only TPE from June 2013 to September 2015: their median age was 58 years (interquartile range, 50 to 70) and eight (57.1%) were male. Body temperature, pressure-adjusted heart rate, white blood cell and platelet counts, coagulation profile, serum creatinine, and multiple organ dysfunction score improved immediately after TPE. In addition, the mean cyclic threshold value of real-time reverse transcriptase polymerase chain reaction for SFTS virus after TPE (mean ± standard deviation, 31.3 ± 2.9) was significantly higher than that before TPE (26.5 ± 2.9; p < 0.001), indicating that serum viral loads decreased after TPE. Finally, 13 of 14 TPE-treated patients (92.8%) recovered from rapidly progressing SFTS without sequelae. Conclusions SFTS patients treated with TPE showed improvements in clinical, laboratory, and virological parameters. These results suggest that TPE would be a therapeutic modality as rescue therapy in patients with rapidly progressing SFTS.http://www.kjim.org/upload/pdf/kjim-2016-194.pdfsevere fever with thrombocytopenia syndromeplasma exchangetherapeutics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jeong Rae Yoo Sun Hyung Kim Young Ree Kim Keun Hwa Lee Won Sup Oh Sang Taek Heo |
spellingShingle |
Jeong Rae Yoo Sun Hyung Kim Young Ree Kim Keun Hwa Lee Won Sup Oh Sang Taek Heo Application of therapeutic plasma exchange in patients having severe fever with thrombocytopenia syndrome The Korean Journal of Internal Medicine severe fever with thrombocytopenia syndrome plasma exchange therapeutics |
author_facet |
Jeong Rae Yoo Sun Hyung Kim Young Ree Kim Keun Hwa Lee Won Sup Oh Sang Taek Heo |
author_sort |
Jeong Rae Yoo |
title |
Application of therapeutic plasma exchange in patients having severe fever with thrombocytopenia syndrome |
title_short |
Application of therapeutic plasma exchange in patients having severe fever with thrombocytopenia syndrome |
title_full |
Application of therapeutic plasma exchange in patients having severe fever with thrombocytopenia syndrome |
title_fullStr |
Application of therapeutic plasma exchange in patients having severe fever with thrombocytopenia syndrome |
title_full_unstemmed |
Application of therapeutic plasma exchange in patients having severe fever with thrombocytopenia syndrome |
title_sort |
application of therapeutic plasma exchange in patients having severe fever with thrombocytopenia syndrome |
publisher |
The Korean Association of Internal Medicine |
series |
The Korean Journal of Internal Medicine |
issn |
1226-3303 2005-6648 |
publishDate |
2019-07-01 |
description |
Background/Aims Severe fever with thrombocytopenia syndrome (SFTS) is a viral hemorrhagic fever with a high fatality rate. However, effective treatments for SFTS cases not responded to supportive therapy have not been established. Herein, we introduced the therapeutic plasma exchange (TPE) in SFTS patients in a tertiary hospital between 2013 and 2015. Methods TPE was performed in patients with rapidly progressing SFTS. Clinical, laboratory, and virological parameters were compared before and after TPE. Results Among 27 confirmed SFTS patients, two patients were treated with TPE and ribavirin combination in May 2013, then, 14 patients with rapidly progressing SFTS patients were treated with only TPE from June 2013 to September 2015: their median age was 58 years (interquartile range, 50 to 70) and eight (57.1%) were male. Body temperature, pressure-adjusted heart rate, white blood cell and platelet counts, coagulation profile, serum creatinine, and multiple organ dysfunction score improved immediately after TPE. In addition, the mean cyclic threshold value of real-time reverse transcriptase polymerase chain reaction for SFTS virus after TPE (mean ± standard deviation, 31.3 ± 2.9) was significantly higher than that before TPE (26.5 ± 2.9; p < 0.001), indicating that serum viral loads decreased after TPE. Finally, 13 of 14 TPE-treated patients (92.8%) recovered from rapidly progressing SFTS without sequelae. Conclusions SFTS patients treated with TPE showed improvements in clinical, laboratory, and virological parameters. These results suggest that TPE would be a therapeutic modality as rescue therapy in patients with rapidly progressing SFTS. |
topic |
severe fever with thrombocytopenia syndrome plasma exchange therapeutics |
url |
http://www.kjim.org/upload/pdf/kjim-2016-194.pdf |
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