Urokinase Gene 3′-UTR T/C Polymorphism Is Associated with Malignancy and ESRD in Idiopathic Membranous Nephropathy
Idiopathic membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome in adults, and 25% of MN patients proceed to ESRD. Urokinase plasminogen activator (uPA) may play an important role in reducing renal fibrosis. This study was conducted to clarify the relationship between u...
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Online Access: | http://dx.doi.org/10.1155/2014/425095 |
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doaj-72ddeb79b86a49b9ad63f92f9d7a9f4d2020-11-24T22:31:45ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/425095425095Urokinase Gene 3′-UTR T/C Polymorphism Is Associated with Malignancy and ESRD in Idiopathic Membranous NephropathyCheng-Hsu Chen0Shih-Yin Chen1Kuo-Hsiung Shu2Mei-Chin Wen3Chi-Hung Cheng4Ming-Ju Wu5Tung-Min Yu6Ya-Wen Chuang7Fuu-Jen Tsai8Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanGraduate Institute of Chinese Medical Science, China Medical University, Taichung, TaiwanDivision of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Pathology, Taichung Veterans General Hospital, Taichung, TaiwanDivision of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanDivision of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanDivision of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanDivision of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanSchool of Medicine, China Medical University, Taichung, TaiwanIdiopathic membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome in adults, and 25% of MN patients proceed to ESRD. Urokinase plasminogen activator (uPA) may play an important role in reducing renal fibrosis. This study was conducted to clarify the relationship between uPA gene polymorphisms and clinical manifestations of MN. We recruited 91 biopsy-diagnosed MN patients and 105 healthy subjects. Genotyping of uPA gene 3′-UTR T/C polymorphism was performed by polymerase chain reaction methods. The genotype distribution had no effect on the development of MN. Thirteen patients (15.9%; P=0.008) acquired malignancies and seventeen (20.7%; P=0.006) patients progressed to ESRD with the C/C genotype, but no patients with the T/C genotype did. In conclusion, we demonstrated that the presence of the uPA gene 3′-UTR C/C genotype was associated with ESRD as well as acquired malignancies in MN patients. These findings should prompt specific considerations for the treatment of MN patients to maintain a balance between treating disease entities and protecting the immune system from cancers.http://dx.doi.org/10.1155/2014/425095 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cheng-Hsu Chen Shih-Yin Chen Kuo-Hsiung Shu Mei-Chin Wen Chi-Hung Cheng Ming-Ju Wu Tung-Min Yu Ya-Wen Chuang Fuu-Jen Tsai |
spellingShingle |
Cheng-Hsu Chen Shih-Yin Chen Kuo-Hsiung Shu Mei-Chin Wen Chi-Hung Cheng Ming-Ju Wu Tung-Min Yu Ya-Wen Chuang Fuu-Jen Tsai Urokinase Gene 3′-UTR T/C Polymorphism Is Associated with Malignancy and ESRD in Idiopathic Membranous Nephropathy BioMed Research International |
author_facet |
Cheng-Hsu Chen Shih-Yin Chen Kuo-Hsiung Shu Mei-Chin Wen Chi-Hung Cheng Ming-Ju Wu Tung-Min Yu Ya-Wen Chuang Fuu-Jen Tsai |
author_sort |
Cheng-Hsu Chen |
title |
Urokinase Gene 3′-UTR T/C Polymorphism Is Associated with Malignancy and ESRD in Idiopathic Membranous Nephropathy |
title_short |
Urokinase Gene 3′-UTR T/C Polymorphism Is Associated with Malignancy and ESRD in Idiopathic Membranous Nephropathy |
title_full |
Urokinase Gene 3′-UTR T/C Polymorphism Is Associated with Malignancy and ESRD in Idiopathic Membranous Nephropathy |
title_fullStr |
Urokinase Gene 3′-UTR T/C Polymorphism Is Associated with Malignancy and ESRD in Idiopathic Membranous Nephropathy |
title_full_unstemmed |
Urokinase Gene 3′-UTR T/C Polymorphism Is Associated with Malignancy and ESRD in Idiopathic Membranous Nephropathy |
title_sort |
urokinase gene 3′-utr t/c polymorphism is associated with malignancy and esrd in idiopathic membranous nephropathy |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
Idiopathic membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome in adults, and 25% of MN patients proceed to ESRD. Urokinase plasminogen activator (uPA) may play an important role in reducing renal fibrosis. This study was conducted to clarify the relationship between uPA gene polymorphisms and clinical manifestations of MN. We recruited 91 biopsy-diagnosed MN patients and 105 healthy subjects. Genotyping of uPA gene 3′-UTR T/C polymorphism was performed by polymerase chain reaction methods. The genotype distribution had no effect on the development of MN. Thirteen patients (15.9%; P=0.008) acquired malignancies and seventeen (20.7%; P=0.006) patients progressed to ESRD with the C/C genotype, but no patients with the T/C genotype did. In conclusion, we demonstrated that the presence of the uPA gene 3′-UTR C/C genotype was associated with ESRD as well as acquired malignancies in MN patients. These findings should prompt specific considerations for the treatment of MN patients to maintain a balance between treating disease entities and protecting the immune system from cancers. |
url |
http://dx.doi.org/10.1155/2014/425095 |
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