Microscopic polyangiitis preceded by combined pulmonary fibrosis and emphysema
A 73-year-old male metalworker was admitted to our hospital with a 3-year history of progressive dry cough. Chest high-resolution computed tomography revealed emphysematous changes and reticular lesions, which is referred to as combined pulmonary fibrosis and emphysema (CPFE). Surgical lung biopsy s...
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doaj-72df56e656ae4ff18e69dbb35fec31952020-11-24T22:17:05ZengElsevierRespiratory Medicine Case Reports2213-00712015-01-0115C12813210.1016/j.rmcr.2015.02.004Microscopic polyangiitis preceded by combined pulmonary fibrosis and emphysemaKyoko Gocho0Keishi Sugino1Keita Sato2Chikako Hasegawa3Toshimasa Uekusa4Sakae Homma5Department of Respiratory Medicine, Toho University Omori Medical Center, 6-11-1, Omori-nishi, Ota-ku, Tokyo 143-8541, JapanDepartment of Respiratory Medicine, Toho University Omori Medical Center, 6-11-1, Omori-nishi, Ota-ku, Tokyo 143-8541, JapanDepartment of Respiratory Medicine, Toho University Omori Medical Center, 6-11-1, Omori-nishi, Ota-ku, Tokyo 143-8541, JapanDepartment of Pathology, Toho University Omori Medical Center, JapanDepartment of Pathology, Japan Labor Health and Welfare Organization Kanto Rosai Hospital, JapanDepartment of Respiratory Medicine, Toho University Omori Medical Center, 6-11-1, Omori-nishi, Ota-ku, Tokyo 143-8541, JapanA 73-year-old male metalworker was admitted to our hospital with a 3-year history of progressive dry cough. Chest high-resolution computed tomography revealed emphysematous changes and reticular lesions, which is referred to as combined pulmonary fibrosis and emphysema (CPFE). Surgical lung biopsy specimens revealed unclassified interstitial pneumonia, including a nonspecific interstitial pneumonia pattern and usual interstitial pneumonia pattern. Two years after his first admission he developed rapid progressive renal dysfunction with an elevated level of myeloperoxidase-antineutrophil cytoplasmic antibody (428 EU). A renal biopsy specimen revealed interstitial nephritis and glomerulonephritis. Consequently, microscopic polyangiitis preceded by CPFE was diagnosed. Despite transient exacerbation of renal involvement, his general condition remained mostly stable during a 2-year period of corticosteroid treatment. He ultimately died from severe pneumococcal pneumonia associated with acute lung injury.http://www.sciencedirect.com/science/article/pii/S2213007115000088Microscopic polyangiitisInterstitial lung diseaseEmphysemaCombined pulmonary fibrosisEmphysema |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kyoko Gocho Keishi Sugino Keita Sato Chikako Hasegawa Toshimasa Uekusa Sakae Homma |
spellingShingle |
Kyoko Gocho Keishi Sugino Keita Sato Chikako Hasegawa Toshimasa Uekusa Sakae Homma Microscopic polyangiitis preceded by combined pulmonary fibrosis and emphysema Respiratory Medicine Case Reports Microscopic polyangiitis Interstitial lung disease Emphysema Combined pulmonary fibrosis Emphysema |
author_facet |
Kyoko Gocho Keishi Sugino Keita Sato Chikako Hasegawa Toshimasa Uekusa Sakae Homma |
author_sort |
Kyoko Gocho |
title |
Microscopic polyangiitis preceded by combined pulmonary fibrosis and emphysema |
title_short |
Microscopic polyangiitis preceded by combined pulmonary fibrosis and emphysema |
title_full |
Microscopic polyangiitis preceded by combined pulmonary fibrosis and emphysema |
title_fullStr |
Microscopic polyangiitis preceded by combined pulmonary fibrosis and emphysema |
title_full_unstemmed |
Microscopic polyangiitis preceded by combined pulmonary fibrosis and emphysema |
title_sort |
microscopic polyangiitis preceded by combined pulmonary fibrosis and emphysema |
publisher |
Elsevier |
series |
Respiratory Medicine Case Reports |
issn |
2213-0071 |
publishDate |
2015-01-01 |
description |
A 73-year-old male metalworker was admitted to our hospital with a 3-year history of progressive dry cough. Chest high-resolution computed tomography revealed emphysematous changes and reticular lesions, which is referred to as combined pulmonary fibrosis and emphysema (CPFE). Surgical lung biopsy specimens revealed unclassified interstitial pneumonia, including a nonspecific interstitial pneumonia pattern and usual interstitial pneumonia pattern. Two years after his first admission he developed rapid progressive renal dysfunction with an elevated level of myeloperoxidase-antineutrophil cytoplasmic antibody (428 EU). A renal biopsy specimen revealed interstitial nephritis and glomerulonephritis. Consequently, microscopic polyangiitis preceded by CPFE was diagnosed. Despite transient exacerbation of renal involvement, his general condition remained mostly stable during a 2-year period of corticosteroid treatment. He ultimately died from severe pneumococcal pneumonia associated with acute lung injury. |
topic |
Microscopic polyangiitis Interstitial lung disease Emphysema Combined pulmonary fibrosis Emphysema |
url |
http://www.sciencedirect.com/science/article/pii/S2213007115000088 |
work_keys_str_mv |
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