Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases
Tumor-induced bone disease is a dynamic process that involves interactions with many cell types. Once metastatic cancer cells reach the bone, they are in contact with many different cell types that are present in the cell-rich bone marrow. These cells include the immune cells, myeloid cells, fibrobl...
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Online Access: | http://dx.doi.org/10.1155/2014/875305 |
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doaj-72dfa33d8ae14ae48c8fe771336331bb2020-11-24T22:41:33ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/875305875305Dissecting the Role of Bone Marrow Stromal Cells on Bone MetastasesDenise Buenrostro0Serk In Park1Julie A. Sterling2Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37212, USACenter for Bone Biology, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, 2215B Garland Avenue, 1235 MRBIV, Nashville, TN 37232, USADepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37212, USATumor-induced bone disease is a dynamic process that involves interactions with many cell types. Once metastatic cancer cells reach the bone, they are in contact with many different cell types that are present in the cell-rich bone marrow. These cells include the immune cells, myeloid cells, fibroblasts, osteoblasts, osteoclasts, and mesenchymal stem cells. Each of these cell populations can influence the behavior or gene expression of both the tumor cells and the bone microenvironment. Additionally, the tumor itself can alter the behavior of these bone marrow cells which further alters both the microenvironment and the tumor cells. While many groups focus on studying these interactions, much remains unknown. A better understanding of the interactions between the tumor cells and the bone microenvironment will improve our knowledge on how tumors establish in bone and may lead to improvements in diagnosing and treating bone metastases. This review details our current knowledge on the interactions between tumor cells that reside in bone and their microenvironment.http://dx.doi.org/10.1155/2014/875305 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Denise Buenrostro Serk In Park Julie A. Sterling |
spellingShingle |
Denise Buenrostro Serk In Park Julie A. Sterling Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases BioMed Research International |
author_facet |
Denise Buenrostro Serk In Park Julie A. Sterling |
author_sort |
Denise Buenrostro |
title |
Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases |
title_short |
Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases |
title_full |
Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases |
title_fullStr |
Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases |
title_full_unstemmed |
Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases |
title_sort |
dissecting the role of bone marrow stromal cells on bone metastases |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
Tumor-induced bone disease is a dynamic process that involves interactions with many cell types. Once metastatic cancer cells reach the bone, they are in contact with many different cell types that are present in the cell-rich bone marrow. These cells include the immune cells, myeloid cells, fibroblasts, osteoblasts, osteoclasts, and mesenchymal stem cells. Each of these cell populations can influence the behavior or gene expression of both the tumor cells and the bone microenvironment. Additionally, the tumor itself can alter the behavior of these bone marrow cells which further alters both the microenvironment and the tumor cells. While many groups focus on studying these interactions, much remains unknown. A better understanding of the interactions between the tumor cells and the bone microenvironment will improve our knowledge on how tumors establish in bone and may lead to improvements in diagnosing and treating bone metastases. This review details our current knowledge on the interactions between tumor cells that reside in bone and their microenvironment. |
url |
http://dx.doi.org/10.1155/2014/875305 |
work_keys_str_mv |
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