The therapeutic effect of mineral water from spring 3 in Baile Tusnad in experimental alcoholic liver disease in rats – an electron microscopic study
The aim of this study was to investigate by transmission electron microscopy the changes occurring in rat hepatocytes following administration of ethyl alcohol for 70 days, as well as to evaluate the effect of mineral water from spring 3 in Baile Tusnad balneoclimatic resort administered for 30 da...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Romanian Association of Balneology, Editura Balneara
2018-09-01
|
Series: | Balneo Research Journal |
Subjects: | |
Online Access: | http://bioclima.ro/Balneo183.pdf |
Summary: | The aim of this study was to investigate by transmission electron microscopy the changes occurring in rat
hepatocytes following administration of ethyl alcohol for 70 days, as well as to evaluate the effect of mineral
water from spring 3 in Baile Tusnad balneoclimatic resort administered for 30 days after completion of ethyl
alcohol administration. After 70 days of ethyl alcohol administration, lipid loading in hepatocytes and a
reduction of the rough endoplasmic reticulum were observed. The smooth endoplasmic reticulum was found
to be much more abundant and in some hepatocytes that contained high lipid amounts, mitochondria had
rarefied matrix and cristae. At 30 days from completion of ethyl alcohol administration, the rats that drank tap
water showed progressively decreasing lipid loading. Also, the smooth endoplasmic reticulum was less
abundant, while the rough endoplasmic reticulum was more abundant than on day 70 of the experiment. The
rats that drank mineral water from spring 3 compared to those that drank tap water over the last 30 days of the
experiment had lower hepatocyte lipid loading and the rough endoplasmic reticulum was much more abundant.
These ultrastructural differences in the degree of lipid loading and the ratio between the smooth and rough
endoplasmic reticulum are due to the beneficial effect of mineral water from spring 3 in Baile Tusnad. |
---|---|
ISSN: | 2069-7597 2069-7619 |