Optic nerve head plasmacytoma as a manifestation of multiple myeloma

• Main Authors: Kaitlin P Sandor, Jonathan A Micieli, Jason H Peragallo
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2021-01-01
• Series: Taiwan Journal of Ophthalmology
• Subjects: multiple myeloma; optic nerve head; optic neuropathy; plasmacytoma
• Online Access: http://www.e-tjo.org/article.asp?issn=2211-5056;year=2021;volume=11;issue=1;spage=97;epage=100;aulast=Sandor

Extramedullary disease in multiple myeloma is uncommon and associated with a poorer prognosis. Extramedullary disease involving the orbit is even more unusual, with optic nerve involvement being rare. We describe an optic nerve head plasmacytoma in a 45-year-old female in the setting of systemic relapsed, refractory IgA kappa multiple myeloma. The case highlights the importance of keeping extramedullary disease spread in the differential for vision loss in a patient with a history of multiple myeloma. In addition, it describes an unusual location for presentation of extramedullary disease, the optic nerve head, which has rarely been described.