European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe

European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe

Background. Non-polio enteroviruses (EVs) and human parechoviruses (PeVs) cause a wide range of human infections. Limited data on their true disease burden exist as standardized European-wide surveillance is lacking. Aims. Our aim is to estimate the disease burden of EV and PeV infections in Europe...

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Main Authors: Heli Harvala, Kimberley S. M. Benschop, Natasa Berginc, Sofie Midgley, Katja Wolthers, Peter Simmonds, Susan Feeney, Jean-Luc Bailly, Audrey Mirand, Thea K. Fischer, on behalf of the ENPEN Hospital-Based Surveillance Network
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Microorganisms
Subjects:
non-polio enteroviruses
surveillance
disease burden
emerging
Online Access:https://www.mdpi.com/2076-2607/9/9/1827
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spelling doaj-72f09d50f89c40a98d8f74a22f6f6e812021-09-26T00:43:20ZengMDPI AGMicroorganisms2076-26072021-08-0191827182710.3390/microorganisms9091827European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in EuropeHeli Harvala0Kimberley S. M. Benschop1Natasa Berginc2Sofie Midgley3Katja Wolthers4Peter Simmonds5Susan Feeney6Jean-Luc Bailly7Audrey Mirand8Thea K. Fischer9on behalf of the ENPEN Hospital-Based Surveillance NetworkNHS Blood and Transplant, Microbiology Services, Colindale, London NW9 5BG, UKNational Institute for Public Health and the Environment, 3721 MA Bilthoven, The NetherlandsLaboratory for Public Health Virology, 1000 Ljubljana, SloveniaThe WHO National Reference Laboratory for Poliovirus, Statens Serum Institute, DK-2300 Copenhagen, DenmarkAmsterdam University Medical Center, 1105 AZ Amsterdam, The NetherlandsNuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UKRegional Virus Laboratory, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland, UKCHU Clermont-Ferrand, National Reference Centre for Enteroviruses and Parechoviruses–Associated Laboratory, 63000 Clermont-Ferrand, FranceCHU Clermont-Ferrand, National Reference Centre for Enteroviruses and Parechoviruses–Associated Laboratory, 63000 Clermont-Ferrand, FranceDepartment of Clinical Research, Nordsjaellands University Hospital, DK-3400 Hilleroed, DenmarkBackground. Non-polio enteroviruses (EVs) and human parechoviruses (PeVs) cause a wide range of human infections. Limited data on their true disease burden exist as standardized European-wide surveillance is lacking. Aims. Our aim is to estimate the disease burden of EV and PeV infections in Europe via establishment of standardized surveillance for hand, foot and mouth disease (HFMD) and respiratory and neurological infections caused by these viruses. We will also assess the sensitivity of assays implemented in the network of participating laboratories so that all EV and PeV types are adequately detected. Plan. The European Non-Polio Enterovirus Network (ENPEN) has developed standardized protocols for a prospective, multi-center and cross-sectional hospital-based pilot study. Protocols include guidance for diagnosis, case definition, detection, characterization and reporting of EV and PeV infections associated with HFMD and respiratory and neurological diseases. Over 30 sites from 17 European countries have already registered to this one pilot study, likely to be commenced in 2022. Benefits. This surveillance will allow European-wide comparison of data on EV and PeV infection. These data will also be used to determine the burden of EV and PeV infections, which is needed to guide the further prevention measures and policies.https://www.mdpi.com/2076-2607/9/9/1827non-polio enterovirusessurveillancedisease burdenemerging
collection DOAJ
language English
format Article
sources DOAJ
author Heli Harvala
Kimberley S. M. Benschop
Natasa Berginc
Sofie Midgley
Katja Wolthers
Peter Simmonds
Susan Feeney
Jean-Luc Bailly
Audrey Mirand
Thea K. Fischer
on behalf of the ENPEN Hospital-Based Surveillance Network
spellingShingle Heli Harvala
Kimberley S. M. Benschop
Natasa Berginc
Sofie Midgley
Katja Wolthers
Peter Simmonds
Susan Feeney
Jean-Luc Bailly
Audrey Mirand
Thea K. Fischer
on behalf of the ENPEN Hospital-Based Surveillance Network
European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe
Microorganisms
non-polio enteroviruses
surveillance
disease burden
emerging
author_facet Heli Harvala
Kimberley S. M. Benschop
Natasa Berginc
Sofie Midgley
Katja Wolthers
Peter Simmonds
Susan Feeney
Jean-Luc Bailly
Audrey Mirand
Thea K. Fischer
on behalf of the ENPEN Hospital-Based Surveillance Network
author_sort Heli Harvala
title European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe
title_short European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe
title_full European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe
title_fullStr European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe
title_full_unstemmed European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe
title_sort european non-polio enterovirus network: introduction of hospital-based surveillance network to understand the true disease burden of non-polio enterovirus and parechovirus infections in europe
publisher MDPI AG
series Microorganisms
issn 2076-2607
publishDate 2021-08-01
description Background. Non-polio enteroviruses (EVs) and human parechoviruses (PeVs) cause a wide range of human infections. Limited data on their true disease burden exist as standardized European-wide surveillance is lacking. Aims. Our aim is to estimate the disease burden of EV and PeV infections in Europe via establishment of standardized surveillance for hand, foot and mouth disease (HFMD) and respiratory and neurological infections caused by these viruses. We will also assess the sensitivity of assays implemented in the network of participating laboratories so that all EV and PeV types are adequately detected. Plan. The European Non-Polio Enterovirus Network (ENPEN) has developed standardized protocols for a prospective, multi-center and cross-sectional hospital-based pilot study. Protocols include guidance for diagnosis, case definition, detection, characterization and reporting of EV and PeV infections associated with HFMD and respiratory and neurological diseases. Over 30 sites from 17 European countries have already registered to this one pilot study, likely to be commenced in 2022. Benefits. This surveillance will allow European-wide comparison of data on EV and PeV infection. These data will also be used to determine the burden of EV and PeV infections, which is needed to guide the further prevention measures and policies.
topic non-polio enteroviruses
surveillance
disease burden
emerging
url https://www.mdpi.com/2076-2607/9/9/1827
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