Anthelmintic activity of Saba senegalensis (A.DC.) Pichon (Apocynaceae) extract against adult worms and eggs of Haemonchus contortus
Objective: To evaluate the anthelmintic property of Saba senegalensis (A.DC) Pichon (Apocynaceae) (S. senegalensis) on Haemonchus contortus that is traditionally used in Burkina Faso for its gastrointestinal parasites treatment. Methods: The lyophilized aqueous decoction of leaves of S. senegalensis...
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Wolters Kluwer Medknow Publications
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doaj-730808f028fa4f87a60b662a777a35782020-11-24T23:06:23ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912016-11-0161194594910.1016/j.apjtb.2016.07.015Anthelmintic activity of Saba senegalensis (A.DC.) Pichon (Apocynaceae) extract against adult worms and eggs of Haemonchus contortusMohamed Bonewendé Belemlilga0Aristide Traoré1Sylvin Ouédraogo2Adama Kaboré3Hamidou Hamadou Tamboura4Innocent Pierre Guissou5Laboratoire de Développement du Médicament, Centre de recherche sur le médicament, Ecole Doctorale de la Santé, Université de Ouagadougou, Ecole Doctorale de Santé, 03 BP 7021 Ouagadougou 03, Burkina FasoDépartement Médecine Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-Ph), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina FasoDépartement Médecine Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-Ph), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina FasoDépartement Productions Animales, Institut de l’Environnement et de Recherches Agricoles(INERA/CNRST), 04 BP 8645 Ouagadougou 04, Burkina FasoDépartement Productions Animales, Institut de l’Environnement et de Recherches Agricoles(INERA/CNRST), 04 BP 8645 Ouagadougou 04, Burkina FasoLaboratoire de Développement du Médicament, Centre de recherche sur le médicament, Ecole Doctorale de la Santé, Université de Ouagadougou, Ecole Doctorale de Santé, 03 BP 7021 Ouagadougou 03, Burkina FasoObjective: To evaluate the anthelmintic property of Saba senegalensis (A.DC) Pichon (Apocynaceae) (S. senegalensis) on Haemonchus contortus that is traditionally used in Burkina Faso for its gastrointestinal parasites treatment. Methods: The lyophilized aqueous decoction of leaves of S. senegalensis at concentrations of 0.10, 1.00, 3.00, 10.00 and 15.00 mg/mL was used on eggs and adult worms of Haemonchus contortus collected from gastrointestinal tract of small ruminant. Results: The LC50 on adult worms was 6.79 mg/mL and 3.25 mg/mL for the leaves of S. senegalensis and the levamisole (reference drug), respectively. Inhibition of hatching assay showed a concentration-dependent manner with an inhibition of 93.63% at the concentration of 15.00 mg/mL of S. senegalensis. Conclusions: These results indicate that the aqueous extract of S. senegalensis possesses an anthelmintic property and may justify its use in traditional medicine for the treatment of gastrointestinal parasites.http://www.sciencedirect.com/science/article/pii/S2221169116307882Saba senegalensisAnthelmintic propertiesHaemonchus contortusIn vitroBurkina Faso |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohamed Bonewendé Belemlilga Aristide Traoré Sylvin Ouédraogo Adama Kaboré Hamidou Hamadou Tamboura Innocent Pierre Guissou |
spellingShingle |
Mohamed Bonewendé Belemlilga Aristide Traoré Sylvin Ouédraogo Adama Kaboré Hamidou Hamadou Tamboura Innocent Pierre Guissou Anthelmintic activity of Saba senegalensis (A.DC.) Pichon (Apocynaceae) extract against adult worms and eggs of Haemonchus contortus Asian Pacific Journal of Tropical Biomedicine Saba senegalensis Anthelmintic properties Haemonchus contortus In vitro Burkina Faso |
author_facet |
Mohamed Bonewendé Belemlilga Aristide Traoré Sylvin Ouédraogo Adama Kaboré Hamidou Hamadou Tamboura Innocent Pierre Guissou |
author_sort |
Mohamed Bonewendé Belemlilga |
title |
Anthelmintic activity of Saba senegalensis (A.DC.) Pichon (Apocynaceae) extract against adult worms and eggs of Haemonchus contortus |
title_short |
Anthelmintic activity of Saba senegalensis (A.DC.) Pichon (Apocynaceae) extract against adult worms and eggs of Haemonchus contortus |
title_full |
Anthelmintic activity of Saba senegalensis (A.DC.) Pichon (Apocynaceae) extract against adult worms and eggs of Haemonchus contortus |
title_fullStr |
Anthelmintic activity of Saba senegalensis (A.DC.) Pichon (Apocynaceae) extract against adult worms and eggs of Haemonchus contortus |
title_full_unstemmed |
Anthelmintic activity of Saba senegalensis (A.DC.) Pichon (Apocynaceae) extract against adult worms and eggs of Haemonchus contortus |
title_sort |
anthelmintic activity of saba senegalensis (a.dc.) pichon (apocynaceae) extract against adult worms and eggs of haemonchus contortus |
publisher |
Wolters Kluwer Medknow Publications |
series |
Asian Pacific Journal of Tropical Biomedicine |
issn |
2221-1691 |
publishDate |
2016-11-01 |
description |
Objective: To evaluate the anthelmintic property of Saba senegalensis (A.DC) Pichon (Apocynaceae) (S. senegalensis) on Haemonchus contortus that is traditionally used in Burkina Faso for its gastrointestinal parasites treatment.
Methods: The lyophilized aqueous decoction of leaves of S. senegalensis at concentrations of 0.10, 1.00, 3.00, 10.00 and 15.00 mg/mL was used on eggs and adult worms of Haemonchus contortus collected from gastrointestinal tract of small ruminant.
Results: The LC50 on adult worms was 6.79 mg/mL and 3.25 mg/mL for the leaves of S. senegalensis and the levamisole (reference drug), respectively. Inhibition of hatching assay showed a concentration-dependent manner with an inhibition of 93.63% at the concentration of 15.00 mg/mL of S. senegalensis.
Conclusions: These results indicate that the aqueous extract of S. senegalensis possesses an anthelmintic property and may justify its use in traditional medicine for the treatment of gastrointestinal parasites. |
topic |
Saba senegalensis Anthelmintic properties Haemonchus contortus In vitro Burkina Faso |
url |
http://www.sciencedirect.com/science/article/pii/S2221169116307882 |
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