A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection
The interplay between fungal pathogens and the innate immune system remains incompletely understood. Here, Wang et al. show that a small protein secreted by Candida albicans induces a TLR2- and TLR4-mediated inflammatory response in a mouse infection model.
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-08950-3 |
| id |
doaj-730ad81173b04795be2435941fb6a493 |
|---|---|
| record_format |
Article |
| spelling |
doaj-730ad81173b04795be2435941fb6a4932021-05-11T12:12:07ZengNature Publishing GroupNature Communications2041-17232019-03-0110111410.1038/s41467-019-08950-3A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infectionWenjuan Wang0Zihou Deng1Hongyu Wu2Qun Zhao3Tiantian Li4Wencheng Zhu5Xiongjun Wang6Longhai Tang7Chengshu Wang8Shu-Zhong Cui9Hui Xiao10Jiangye Chen11State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of SciencesCAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, CAS Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of SciencesState Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of SciencesState Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of SciencesCAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, CAS Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of SciencesState Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of SciencesState Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of SciencesSuzhou Blood CenterCAS Key Laboratory of Insect Developmental and Evolutionary Biology, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of SciencesState Key Laboratory of Respiratory Diseases, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou Medical UniversityCAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, CAS Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of SciencesState Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of SciencesThe interplay between fungal pathogens and the innate immune system remains incompletely understood. Here, Wang et al. show that a small protein secreted by Candida albicans induces a TLR2- and TLR4-mediated inflammatory response in a mouse infection model.https://doi.org/10.1038/s41467-019-08950-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Wenjuan Wang Zihou Deng Hongyu Wu Qun Zhao Tiantian Li Wencheng Zhu Xiongjun Wang Longhai Tang Chengshu Wang Shu-Zhong Cui Hui Xiao Jiangye Chen |
| spellingShingle |
Wenjuan Wang Zihou Deng Hongyu Wu Qun Zhao Tiantian Li Wencheng Zhu Xiongjun Wang Longhai Tang Chengshu Wang Shu-Zhong Cui Hui Xiao Jiangye Chen A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection Nature Communications |
| author_facet |
Wenjuan Wang Zihou Deng Hongyu Wu Qun Zhao Tiantian Li Wencheng Zhu Xiongjun Wang Longhai Tang Chengshu Wang Shu-Zhong Cui Hui Xiao Jiangye Chen |
| author_sort |
Wenjuan Wang |
| title |
A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection |
| title_short |
A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection |
| title_full |
A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection |
| title_fullStr |
A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection |
| title_full_unstemmed |
A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection |
| title_sort |
small secreted protein triggers a tlr2/4-dependent inflammatory response during invasive candida albicans infection |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-03-01 |
| description |
The interplay between fungal pathogens and the innate immune system remains incompletely understood. Here, Wang et al. show that a small protein secreted by Candida albicans induces a TLR2- and TLR4-mediated inflammatory response in a mouse infection model. |
| url |
https://doi.org/10.1038/s41467-019-08950-3 |
| work_keys_str_mv |
AT wenjuanwang asmallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT zihoudeng asmallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT hongyuwu asmallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT qunzhao asmallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT tiantianli asmallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT wenchengzhu asmallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT xiongjunwang asmallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT longhaitang asmallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT chengshuwang asmallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT shuzhongcui asmallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT huixiao asmallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT jiangyechen asmallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT wenjuanwang smallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT zihoudeng smallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT hongyuwu smallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT qunzhao smallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT tiantianli smallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT wenchengzhu smallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT xiongjunwang smallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT longhaitang smallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT chengshuwang smallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT shuzhongcui smallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT huixiao smallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection AT jiangyechen smallsecretedproteintriggersatlr24dependentinflammatoryresponseduringinvasivecandidaalbicansinfection |
| _version_ |
1721445271339008000 |