Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genes

Here, the authors quantify early gametocyte-committed ring (gc-ring) stage Plasmodium falciparum parasites in 260 malaria patients 10 days before maturation to transmissible stage V gametocytes, and show that the ratio of circulating gc-rings is positively correlated with parasitemia and negatively...

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Main Authors:	Miho Usui, Surendra K. Prajapati, Ruth Ayanful-Torgby, Festus K. Acquah, Elizabeth Cudjoe, Courage Kakaney, Jones A. Amponsah, Evans K. Obboh, Deepti K. Reddy, Michelle C. Barbeau, Lacy M. Simons, Beata Czesny, Sorana Raiciulescu, Cara Olsen, Benjamin K. Abuaku, Linda E. Amoah, Kim C. Williamson
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-10172-6

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spelling	doaj-73141292ad324d40a033d356781f23b72021-05-11T11:48:55ZengNature Publishing GroupNature Communications2041-17232019-05-0110111510.1038/s41467-019-10172-6Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genesMiho Usui0Surendra K. Prajapati1Ruth Ayanful-Torgby2Festus K. Acquah3Elizabeth Cudjoe4Courage Kakaney5Jones A. Amponsah6Evans K. Obboh7Deepti K. Reddy8Michelle C. Barbeau9Lacy M. Simons10Beata Czesny11Sorana Raiciulescu12Cara Olsen13Benjamin K. Abuaku14Linda E. Amoah15Kim C. Williamson16Uniformed Services University of the Health SciencesUniformed Services University of the Health SciencesNoguchi Memorial Institute for Medical Research, University of GhanaNoguchi Memorial Institute for Medical Research, University of GhanaNoguchi Memorial Institute for Medical Research, University of GhanaNoguchi Memorial Institute for Medical Research, University of GhanaNoguchi Memorial Institute for Medical Research, University of GhanaSchool of Medical Sciences, University of Cape CoastUniformed Services University of the Health SciencesUniformed Services University of the Health SciencesLoyola University ChicagoLoyola University ChicagoUniformed Services University of the Health SciencesUniformed Services University of the Health SciencesNoguchi Memorial Institute for Medical Research, University of GhanaNoguchi Memorial Institute for Medical Research, University of GhanaUniformed Services University of the Health SciencesHere, the authors quantify early gametocyte-committed ring (gc-ring) stage Plasmodium falciparum parasites in 260 malaria patients 10 days before maturation to transmissible stage V gametocytes, and show that the ratio of circulating gc-rings is positively correlated with parasitemia and negatively correlated with body temperature.https://doi.org/10.1038/s41467-019-10172-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Miho Usui Surendra K. Prajapati Ruth Ayanful-Torgby Festus K. Acquah Elizabeth Cudjoe Courage Kakaney Jones A. Amponsah Evans K. Obboh Deepti K. Reddy Michelle C. Barbeau Lacy M. Simons Beata Czesny Sorana Raiciulescu Cara Olsen Benjamin K. Abuaku Linda E. Amoah Kim C. Williamson
spellingShingle	Miho Usui Surendra K. Prajapati Ruth Ayanful-Torgby Festus K. Acquah Elizabeth Cudjoe Courage Kakaney Jones A. Amponsah Evans K. Obboh Deepti K. Reddy Michelle C. Barbeau Lacy M. Simons Beata Czesny Sorana Raiciulescu Cara Olsen Benjamin K. Abuaku Linda E. Amoah Kim C. Williamson Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genes Nature Communications
author_facet	Miho Usui Surendra K. Prajapati Ruth Ayanful-Torgby Festus K. Acquah Elizabeth Cudjoe Courage Kakaney Jones A. Amponsah Evans K. Obboh Deepti K. Reddy Michelle C. Barbeau Lacy M. Simons Beata Czesny Sorana Raiciulescu Cara Olsen Benjamin K. Abuaku Linda E. Amoah Kim C. Williamson
author_sort	Miho Usui
title	Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genes
title_short	Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genes
title_full	Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genes
title_fullStr	Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genes
title_full_unstemmed	Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genes
title_sort	plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and gdv1-dependent genes
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-05-01
description	Here, the authors quantify early gametocyte-committed ring (gc-ring) stage Plasmodium falciparum parasites in 260 malaria patients 10 days before maturation to transmissible stage V gametocytes, and show that the ratio of circulating gc-rings is positively correlated with parasitemia and negatively correlated with body temperature.
url	https://doi.org/10.1038/s41467-019-10172-6
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Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genes

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