ASSESSMENT OF FREQUENCY OF ALLOIMMUNIZATION AND ERYTHROCYTE AUTOIMMUNIZATION IN TRANSFUSION DEPENDENT THALASSEMIA PATIENTS
Life-long red blood transfusion remains the main treatment for severe thalassemia. The development of hemolytic alloantibodies and erythrocyte autoantibodies complicated transfusion therapy in thalassemia patients. The frequency causes and prevention of this phenomenon among 80 transfused thalassem...
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Tehran University of Medical Sciences
2008-04-01
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doaj-731aadc255b54d848cdf1c96ff1a20832020-11-25T03:45:52ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942008-04-01462ASSESSMENT OF FREQUENCY OF ALLOIMMUNIZATION AND ERYTHROCYTE AUTOIMMUNIZATION IN TRANSFUSION DEPENDENT THALASSEMIA PATIENTS S. Ansari0 P. Voosogh S. Moshtaghian1 Life-long red blood transfusion remains the main treatment for severe thalassemia. The development of hemolytic alloantibodies and erythrocyte autoantibodies complicated transfusion therapy in thalassemia patients. The frequency causes and prevention of this phenomenon among 80 transfused thalassemia patients were evaluated in Ali Asghar Children's Hospital during 1998-2004 in a cross-sectional study. In our study the mean age at the initiation of transfusion was 1.7 years (SD = 1.94) and mean interval of transfusion 33.73 day (SD = 20.74). Autoimmunization in 15 patients was positive and 8 patients had hemolytic reaction in transfusion. Our data show that alloimmunization to minor erythrocyte antigens and erythrocyte autoimmunization of significant clinical variables, are frequent findings in transfused thalassemia patients. However data suggest that prevalence of immunization in our patients is less than other Asian countries. https://acta.tums.ac.ir/index.php/acta/article/view/3458alloimmunizationautoimmunizationcoomb’s testhemolytic reaction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
S. Ansari P. Voosogh S. Moshtaghian |
spellingShingle |
S. Ansari P. Voosogh S. Moshtaghian ASSESSMENT OF FREQUENCY OF ALLOIMMUNIZATION AND ERYTHROCYTE AUTOIMMUNIZATION IN TRANSFUSION DEPENDENT THALASSEMIA PATIENTS Acta Medica Iranica alloimmunization autoimmunization coomb’s test hemolytic reaction |
author_facet |
S. Ansari P. Voosogh S. Moshtaghian |
author_sort |
S. Ansari |
title |
ASSESSMENT OF FREQUENCY OF ALLOIMMUNIZATION AND ERYTHROCYTE AUTOIMMUNIZATION IN TRANSFUSION DEPENDENT THALASSEMIA PATIENTS |
title_short |
ASSESSMENT OF FREQUENCY OF ALLOIMMUNIZATION AND ERYTHROCYTE AUTOIMMUNIZATION IN TRANSFUSION DEPENDENT THALASSEMIA PATIENTS |
title_full |
ASSESSMENT OF FREQUENCY OF ALLOIMMUNIZATION AND ERYTHROCYTE AUTOIMMUNIZATION IN TRANSFUSION DEPENDENT THALASSEMIA PATIENTS |
title_fullStr |
ASSESSMENT OF FREQUENCY OF ALLOIMMUNIZATION AND ERYTHROCYTE AUTOIMMUNIZATION IN TRANSFUSION DEPENDENT THALASSEMIA PATIENTS |
title_full_unstemmed |
ASSESSMENT OF FREQUENCY OF ALLOIMMUNIZATION AND ERYTHROCYTE AUTOIMMUNIZATION IN TRANSFUSION DEPENDENT THALASSEMIA PATIENTS |
title_sort |
assessment of frequency of alloimmunization and erythrocyte autoimmunization in transfusion dependent thalassemia patients |
publisher |
Tehran University of Medical Sciences |
series |
Acta Medica Iranica |
issn |
0044-6025 1735-9694 |
publishDate |
2008-04-01 |
description |
Life-long red blood transfusion remains the main treatment for severe thalassemia. The development of hemolytic alloantibodies and erythrocyte autoantibodies complicated transfusion therapy in thalassemia patients. The frequency causes and prevention of this phenomenon among 80 transfused thalassemia patients were evaluated in Ali Asghar Children's Hospital during 1998-2004 in a cross-sectional study. In our study the mean age at the initiation of transfusion was 1.7 years (SD = 1.94) and mean interval of transfusion 33.73 day (SD = 20.74). Autoimmunization in 15 patients was positive and 8 patients had hemolytic reaction in transfusion. Our data show that alloimmunization to minor erythrocyte antigens and erythrocyte autoimmunization of significant clinical variables, are frequent findings in transfused thalassemia patients. However data suggest that prevalence of immunization in our patients is less than other Asian countries.
|
topic |
alloimmunization autoimmunization coomb’s test hemolytic reaction |
url |
https://acta.tums.ac.ir/index.php/acta/article/view/3458 |
work_keys_str_mv |
AT sansari assessmentoffrequencyofalloimmunizationanderythrocyteautoimmunizationintransfusiondependentthalassemiapatients AT pvoosoghsmoshtaghian assessmentoffrequencyofalloimmunizationanderythrocyteautoimmunizationintransfusiondependentthalassemiapatients |
_version_ |
1724509293228589056 |