Acute kidney injury successfully treated with autologous granulocyte colony‐stimulating factor‐mobilized peripheral blood CD34‐positive cell transplantation: A first‐in‐human report
Abstract A 36‐year‐old man with severe acute kidney injury (AKI) was admitted to Shonan Kamakura General Hospital in Japan. He was diagnosed with refractory hypertension based on a severely elevated blood pressure of 224/116 mmHg and retinal, cardiac, and brain damage revealed by electrocardiogram,...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2021-09-01
|
Series: | Stem Cells Translational Medicine |
Subjects: | |
Online Access: | https://doi.org/10.1002/sctm.20-0561 |
id |
doaj-7335bc302ead47a89c9297e96ac605aa |
---|---|
record_format |
Article |
spelling |
doaj-7335bc302ead47a89c9297e96ac605aa2021-08-22T15:25:57ZengWileyStem Cells Translational Medicine2157-65642157-65802021-09-011091253125710.1002/sctm.20-0561Acute kidney injury successfully treated with autologous granulocyte colony‐stimulating factor‐mobilized peripheral blood CD34‐positive cell transplantation: A first‐in‐human reportHiroyuki Suzuki0Takayasu Ohtake1Toshitaka Tsukiyama2Marie Morota3Kunihiro Ishioka4Hidekazu Moriya5Yasuhiro Mochida6Sumi Hidaka7Tsutomu Sato8Takayuki Asahara9Shuzo Kobayashi10Kidney Disease and Transplant Center Shonan Kamakura General Hospital Kamakura JapanKidney Disease and Transplant Center Shonan Kamakura General Hospital Kamakura JapanDepartment of Radiology and Interventional Radiology Shonan Kamakura General Hospital Kamakura JapanKidney Disease and Transplant Center Shonan Kamakura General Hospital Kamakura JapanKidney Disease and Transplant Center Shonan Kamakura General Hospital Kamakura JapanKidney Disease and Transplant Center Shonan Kamakura General Hospital Kamakura JapanKidney Disease and Transplant Center Shonan Kamakura General Hospital Kamakura JapanKidney Disease and Transplant Center Shonan Kamakura General Hospital Kamakura JapanClinical Laboratory Shonan Kamakura General Hospital Kamakura JapanRegenerative Medicine Science Tokai University School of Medicine Isehara JapanKidney Disease and Transplant Center Shonan Kamakura General Hospital Kamakura JapanAbstract A 36‐year‐old man with severe acute kidney injury (AKI) was admitted to Shonan Kamakura General Hospital in Japan. He was diagnosed with refractory hypertension based on a severely elevated blood pressure of 224/116 mmHg and retinal, cardiac, and brain damage revealed by electrocardiogram, fundoscopy, and magnetic resonance imaging, respectively. Although hemodialysis was withdrawn following strict blood pressure control by an angiotensin receptor blocker, severe kidney insufficiency persisted. Therefore, we performed an autologous granulocyte colony‐stimulating factor‐mobilized peripheral blood CD34‐positive cell transplantation. Collected CD34‐positive cells were directly infused to both renal arteries. The patient's general condition was unremarkable after intervention, and the serum creatinine level gradually improved to 2.96 mg/dL 23 weeks after cell therapy. Although transient fever and thrombocytosis were observed after intervention, no major adverse events were observed. This patient is the first case in a phase I/II clinical trial of autologous granulocyte colony‐stimulating factor‐mobilized peripheral blood CD34‐positive cell transplantation for severe AKI with a CD34‐positive cell dose‐escalating protocol (trial number jRCTb030190231).https://doi.org/10.1002/sctm.20-0561CD34+clinical trialsgranulocyte‐colony stimulating factor (G‐CSF)hematopoietic stem cells (HSCs)kidneystem cell transplantation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hiroyuki Suzuki Takayasu Ohtake Toshitaka Tsukiyama Marie Morota Kunihiro Ishioka Hidekazu Moriya Yasuhiro Mochida Sumi Hidaka Tsutomu Sato Takayuki Asahara Shuzo Kobayashi |
spellingShingle |
Hiroyuki Suzuki Takayasu Ohtake Toshitaka Tsukiyama Marie Morota Kunihiro Ishioka Hidekazu Moriya Yasuhiro Mochida Sumi Hidaka Tsutomu Sato Takayuki Asahara Shuzo Kobayashi Acute kidney injury successfully treated with autologous granulocyte colony‐stimulating factor‐mobilized peripheral blood CD34‐positive cell transplantation: A first‐in‐human report Stem Cells Translational Medicine CD34+ clinical trials granulocyte‐colony stimulating factor (G‐CSF) hematopoietic stem cells (HSCs) kidney stem cell transplantation |
author_facet |
Hiroyuki Suzuki Takayasu Ohtake Toshitaka Tsukiyama Marie Morota Kunihiro Ishioka Hidekazu Moriya Yasuhiro Mochida Sumi Hidaka Tsutomu Sato Takayuki Asahara Shuzo Kobayashi |
author_sort |
Hiroyuki Suzuki |
title |
Acute kidney injury successfully treated with autologous granulocyte colony‐stimulating factor‐mobilized peripheral blood CD34‐positive cell transplantation: A first‐in‐human report |
title_short |
Acute kidney injury successfully treated with autologous granulocyte colony‐stimulating factor‐mobilized peripheral blood CD34‐positive cell transplantation: A first‐in‐human report |
title_full |
Acute kidney injury successfully treated with autologous granulocyte colony‐stimulating factor‐mobilized peripheral blood CD34‐positive cell transplantation: A first‐in‐human report |
title_fullStr |
Acute kidney injury successfully treated with autologous granulocyte colony‐stimulating factor‐mobilized peripheral blood CD34‐positive cell transplantation: A first‐in‐human report |
title_full_unstemmed |
Acute kidney injury successfully treated with autologous granulocyte colony‐stimulating factor‐mobilized peripheral blood CD34‐positive cell transplantation: A first‐in‐human report |
title_sort |
acute kidney injury successfully treated with autologous granulocyte colony‐stimulating factor‐mobilized peripheral blood cd34‐positive cell transplantation: a first‐in‐human report |
publisher |
Wiley |
series |
Stem Cells Translational Medicine |
issn |
2157-6564 2157-6580 |
publishDate |
2021-09-01 |
description |
Abstract A 36‐year‐old man with severe acute kidney injury (AKI) was admitted to Shonan Kamakura General Hospital in Japan. He was diagnosed with refractory hypertension based on a severely elevated blood pressure of 224/116 mmHg and retinal, cardiac, and brain damage revealed by electrocardiogram, fundoscopy, and magnetic resonance imaging, respectively. Although hemodialysis was withdrawn following strict blood pressure control by an angiotensin receptor blocker, severe kidney insufficiency persisted. Therefore, we performed an autologous granulocyte colony‐stimulating factor‐mobilized peripheral blood CD34‐positive cell transplantation. Collected CD34‐positive cells were directly infused to both renal arteries. The patient's general condition was unremarkable after intervention, and the serum creatinine level gradually improved to 2.96 mg/dL 23 weeks after cell therapy. Although transient fever and thrombocytosis were observed after intervention, no major adverse events were observed. This patient is the first case in a phase I/II clinical trial of autologous granulocyte colony‐stimulating factor‐mobilized peripheral blood CD34‐positive cell transplantation for severe AKI with a CD34‐positive cell dose‐escalating protocol (trial number jRCTb030190231). |
topic |
CD34+ clinical trials granulocyte‐colony stimulating factor (G‐CSF) hematopoietic stem cells (HSCs) kidney stem cell transplantation |
url |
https://doi.org/10.1002/sctm.20-0561 |
work_keys_str_mv |
AT hiroyukisuzuki acutekidneyinjurysuccessfullytreatedwithautologousgranulocytecolonystimulatingfactormobilizedperipheralbloodcd34positivecelltransplantationafirstinhumanreport AT takayasuohtake acutekidneyinjurysuccessfullytreatedwithautologousgranulocytecolonystimulatingfactormobilizedperipheralbloodcd34positivecelltransplantationafirstinhumanreport AT toshitakatsukiyama acutekidneyinjurysuccessfullytreatedwithautologousgranulocytecolonystimulatingfactormobilizedperipheralbloodcd34positivecelltransplantationafirstinhumanreport AT mariemorota acutekidneyinjurysuccessfullytreatedwithautologousgranulocytecolonystimulatingfactormobilizedperipheralbloodcd34positivecelltransplantationafirstinhumanreport AT kunihiroishioka acutekidneyinjurysuccessfullytreatedwithautologousgranulocytecolonystimulatingfactormobilizedperipheralbloodcd34positivecelltransplantationafirstinhumanreport AT hidekazumoriya acutekidneyinjurysuccessfullytreatedwithautologousgranulocytecolonystimulatingfactormobilizedperipheralbloodcd34positivecelltransplantationafirstinhumanreport AT yasuhiromochida acutekidneyinjurysuccessfullytreatedwithautologousgranulocytecolonystimulatingfactormobilizedperipheralbloodcd34positivecelltransplantationafirstinhumanreport AT sumihidaka acutekidneyinjurysuccessfullytreatedwithautologousgranulocytecolonystimulatingfactormobilizedperipheralbloodcd34positivecelltransplantationafirstinhumanreport AT tsutomusato acutekidneyinjurysuccessfullytreatedwithautologousgranulocytecolonystimulatingfactormobilizedperipheralbloodcd34positivecelltransplantationafirstinhumanreport AT takayukiasahara acutekidneyinjurysuccessfullytreatedwithautologousgranulocytecolonystimulatingfactormobilizedperipheralbloodcd34positivecelltransplantationafirstinhumanreport AT shuzokobayashi acutekidneyinjurysuccessfullytreatedwithautologousgranulocytecolonystimulatingfactormobilizedperipheralbloodcd34positivecelltransplantationafirstinhumanreport |
_version_ |
1721199332420485120 |