The Dilemma of Cure and Damage in Oligodendroglioma: Ways to Tip the Balance Away from the Damage
Current treatments for oligodendrogliomas are powerful but have a negative impact on the rest of the body. The bone marrow is damaged by the chemotherapeutics, but other parts of the body are also affected. In this paper, the current treatment method and its collateral damage is described. Therefore...
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doaj-733dd87df36946108c893ebf126f0c052020-11-25T00:32:58ZengMDPI AGCancers2072-66942018-11-01101143110.3390/cancers10110431cancers10110431The Dilemma of Cure and Damage in Oligodendroglioma: Ways to Tip the Balance Away from the DamageRuurd Torensma0Department of Tumorimmunology, Radboud Institute for Molecular Life Sciences, RadboudUMC, Geert Grooteplein 28, 6525GA Nijmegen, The NetherlandsCurrent treatments for oligodendrogliomas are powerful but have a negative impact on the rest of the body. The bone marrow is damaged by the chemotherapeutics, but other parts of the body are also affected. In this paper, the current treatment method and its collateral damage is described. Therefore, therapies are needed that are more effective against the tumor while having less negative effects on the patient’s quality of life. Some potential therapies include optimal removal of the tumor by fluorescent-guided surgery (FGS), intraoperative desorption electrospray ionization-mass spectrometry (DESI-MS), better monitoring of the effects of therapy by pseudo-coloring shades of gray of MRI pictures, and using recent data from RNA sequencing of single cells and immunotherapy. These are all open new ways of treating this tumor. The RNA sequencing of single tumor cells unravels specific tumor antigens present in the differentiation status of the cancer cell. Stem cell antigens were expressed in dividing cells, while hypoxia inducible factor-α (HIF-1α) is expressed in all tumor cells. Cancer stem cell antigens can be loaded on dendritic cells to induce cytotoxic T-cells directed to cancer stem cells. These recent discoveries suggest a better quality of life with the same overall survival.https://www.mdpi.com/2072-6694/10/11/431oligodendrogliomasingle-cell RNA sequencingpseudo-coloring MRIDendritic cell vaccinationfluorescence-guided surgerymass spectrometry surgeryquality of life |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ruurd Torensma |
spellingShingle |
Ruurd Torensma The Dilemma of Cure and Damage in Oligodendroglioma: Ways to Tip the Balance Away from the Damage Cancers oligodendroglioma single-cell RNA sequencing pseudo-coloring MRI Dendritic cell vaccination fluorescence-guided surgery mass spectrometry surgery quality of life |
author_facet |
Ruurd Torensma |
author_sort |
Ruurd Torensma |
title |
The Dilemma of Cure and Damage in Oligodendroglioma: Ways to Tip the Balance Away from the Damage |
title_short |
The Dilemma of Cure and Damage in Oligodendroglioma: Ways to Tip the Balance Away from the Damage |
title_full |
The Dilemma of Cure and Damage in Oligodendroglioma: Ways to Tip the Balance Away from the Damage |
title_fullStr |
The Dilemma of Cure and Damage in Oligodendroglioma: Ways to Tip the Balance Away from the Damage |
title_full_unstemmed |
The Dilemma of Cure and Damage in Oligodendroglioma: Ways to Tip the Balance Away from the Damage |
title_sort |
dilemma of cure and damage in oligodendroglioma: ways to tip the balance away from the damage |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2018-11-01 |
description |
Current treatments for oligodendrogliomas are powerful but have a negative impact on the rest of the body. The bone marrow is damaged by the chemotherapeutics, but other parts of the body are also affected. In this paper, the current treatment method and its collateral damage is described. Therefore, therapies are needed that are more effective against the tumor while having less negative effects on the patient’s quality of life. Some potential therapies include optimal removal of the tumor by fluorescent-guided surgery (FGS), intraoperative desorption electrospray ionization-mass spectrometry (DESI-MS), better monitoring of the effects of therapy by pseudo-coloring shades of gray of MRI pictures, and using recent data from RNA sequencing of single cells and immunotherapy. These are all open new ways of treating this tumor. The RNA sequencing of single tumor cells unravels specific tumor antigens present in the differentiation status of the cancer cell. Stem cell antigens were expressed in dividing cells, while hypoxia inducible factor-α (HIF-1α) is expressed in all tumor cells. Cancer stem cell antigens can be loaded on dendritic cells to induce cytotoxic T-cells directed to cancer stem cells. These recent discoveries suggest a better quality of life with the same overall survival. |
topic |
oligodendroglioma single-cell RNA sequencing pseudo-coloring MRI Dendritic cell vaccination fluorescence-guided surgery mass spectrometry surgery quality of life |
url |
https://www.mdpi.com/2072-6694/10/11/431 |
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