HE CHARACTERISTICS OF GENETIC POLYMORPHISM OF HLA-ANTIGENS IN ACQUIRED APLASTIC ANEMIA IN CHILDREN

HE CHARACTERISTICS OF GENETIC POLYMORPHISM OF HLA-ANTIGENS IN ACQUIRED APLASTIC ANEMIA IN CHILDREN

This study presents the genetic polymorphism of HLA-antigens in acquired aplastic anemia (AAA) in 147 children (85 boys и 62 girls) aged 1 to 18 with. The control group is consisted of 1700 umbilical cord blood samples of healthy newborns. The genetic polymorphism of HLA was studied in groups of chi...

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Bibliographic Details
Main Authors: A A Chumak, T A Astrelina, M V Yakovleva, Lidiya L'vovna Lebedeva, L L TV Pukhlikova, Z M Dishlevaya, A N Arkhipova, M M Azova
Format: Article
Language:English
Published: Peoples’ Friendship University of Russia (RUDN University) 2013-12-01
Series:RUDN Journal of Medicine
Subjects:
антигены HLA-системы
приобретенная апластическая анемия
дети
Online Access:http://journals.rudn.ru/medicine/article/view/3200
Description
Summary:This study presents the genetic polymorphism of HLA-antigens in acquired aplastic anemia (AAA) in 147 children (85 boys и 62 girls) aged 1 to 18 with. The control group is consisted of 1700 umbilical cord blood samples of healthy newborns. The genetic polymorphism of HLA was studied in groups of children with AAA, divided by gender and age. Our results revealed distinction in HLA-markers of predisposition and sustainability to AAA. Possible differences in factors of immunogenetic predisposition suggest different mechanisms involved in the development of the disease in different groups of children and reconsider the existing model of the pathogenesis of AAA.
ISSN:2313-0245
2313-0261

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