HE CHARACTERISTICS OF GENETIC POLYMORPHISM OF HLA-ANTIGENS IN ACQUIRED APLASTIC ANEMIA IN CHILDREN
This study presents the genetic polymorphism of HLA-antigens in acquired aplastic anemia (AAA) in 147 children (85 boys и 62 girls) aged 1 to 18 with. The control group is consisted of 1700 umbilical cord blood samples of healthy newborns. The genetic polymorphism of HLA was studied in groups of chi...
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Peoples’ Friendship University of Russia (RUDN University)
2013-12-01
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Online Access: | http://journals.rudn.ru/medicine/article/view/3200 |
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doaj-734c60e848e24bcb87b80eb77825dfb12020-11-25T00:31:50ZengPeoples’ Friendship University of Russia (RUDN University)RUDN Journal of Medicine2313-02452313-02612013-12-010115193200HE CHARACTERISTICS OF GENETIC POLYMORPHISM OF HLA-ANTIGENS IN ACQUIRED APLASTIC ANEMIA IN CHILDRENA A Chumak0T A Astrelina1M V Yakovleva2Lidiya L'vovna Lebedeva3L L TV Pukhlikova4Z M Dishlevaya5A N Arkhipova6M M Azova7ГБУЗ «Банк стволовых клеток Департамента Здравоохранения города Москвы»ГБУЗ «Банк стволовых клеток Департамента Здравоохранения города Москвы»ГБУЗ «Банк стволовых клеток Департамента Здравоохранения города Москвы»ГБУЗ «Банк стволовых клеток Департамента Здравоохранения города Москвы»ГБУЗ «Банк стволовых клеток Департамента Здравоохранения города Москвы»ФГБУ РДКБ Минздравсоцразвития РоссииФГБУ РДКБ Минздравсоцразвития РоссииРоссийский университет дружбы народовThis study presents the genetic polymorphism of HLA-antigens in acquired aplastic anemia (AAA) in 147 children (85 boys и 62 girls) aged 1 to 18 with. The control group is consisted of 1700 umbilical cord blood samples of healthy newborns. The genetic polymorphism of HLA was studied in groups of children with AAA, divided by gender and age. Our results revealed distinction in HLA-markers of predisposition and sustainability to AAA. Possible differences in factors of immunogenetic predisposition suggest different mechanisms involved in the development of the disease in different groups of children and reconsider the existing model of the pathogenesis of AAA.http://journals.rudn.ru/medicine/article/view/3200антигены HLA-системыприобретенная апластическая анемиядети |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A A Chumak T A Astrelina M V Yakovleva Lidiya L'vovna Lebedeva L L TV Pukhlikova Z M Dishlevaya A N Arkhipova M M Azova |
spellingShingle |
A A Chumak T A Astrelina M V Yakovleva Lidiya L'vovna Lebedeva L L TV Pukhlikova Z M Dishlevaya A N Arkhipova M M Azova HE CHARACTERISTICS OF GENETIC POLYMORPHISM OF HLA-ANTIGENS IN ACQUIRED APLASTIC ANEMIA IN CHILDREN RUDN Journal of Medicine антигены HLA-системы приобретенная апластическая анемия дети |
author_facet |
A A Chumak T A Astrelina M V Yakovleva Lidiya L'vovna Lebedeva L L TV Pukhlikova Z M Dishlevaya A N Arkhipova M M Azova |
author_sort |
A A Chumak |
title |
HE CHARACTERISTICS OF GENETIC POLYMORPHISM OF HLA-ANTIGENS IN ACQUIRED APLASTIC ANEMIA IN CHILDREN |
title_short |
HE CHARACTERISTICS OF GENETIC POLYMORPHISM OF HLA-ANTIGENS IN ACQUIRED APLASTIC ANEMIA IN CHILDREN |
title_full |
HE CHARACTERISTICS OF GENETIC POLYMORPHISM OF HLA-ANTIGENS IN ACQUIRED APLASTIC ANEMIA IN CHILDREN |
title_fullStr |
HE CHARACTERISTICS OF GENETIC POLYMORPHISM OF HLA-ANTIGENS IN ACQUIRED APLASTIC ANEMIA IN CHILDREN |
title_full_unstemmed |
HE CHARACTERISTICS OF GENETIC POLYMORPHISM OF HLA-ANTIGENS IN ACQUIRED APLASTIC ANEMIA IN CHILDREN |
title_sort |
he characteristics of genetic polymorphism of hla-antigens in acquired aplastic anemia in children |
publisher |
Peoples’ Friendship University of Russia (RUDN University) |
series |
RUDN Journal of Medicine |
issn |
2313-0245 2313-0261 |
publishDate |
2013-12-01 |
description |
This study presents the genetic polymorphism of HLA-antigens in acquired aplastic anemia (AAA) in 147 children (85 boys и 62 girls) aged 1 to 18 with. The control group is consisted of 1700 umbilical cord blood samples of healthy newborns. The genetic polymorphism of HLA was studied in groups of children with AAA, divided by gender and age. Our results revealed distinction in HLA-markers of predisposition and sustainability to AAA. Possible differences in factors of immunogenetic predisposition suggest different mechanisms involved in the development of the disease in different groups of children and reconsider the existing model of the pathogenesis of AAA. |
topic |
антигены HLA-системы приобретенная апластическая анемия дети |
url |
http://journals.rudn.ru/medicine/article/view/3200 |
work_keys_str_mv |
AT aachumak hecharacteristicsofgeneticpolymorphismofhlaantigensinacquiredaplasticanemiainchildren AT taastrelina hecharacteristicsofgeneticpolymorphismofhlaantigensinacquiredaplasticanemiainchildren AT mvyakovleva hecharacteristicsofgeneticpolymorphismofhlaantigensinacquiredaplasticanemiainchildren AT lidiyalvovnalebedeva hecharacteristicsofgeneticpolymorphismofhlaantigensinacquiredaplasticanemiainchildren AT lltvpukhlikova hecharacteristicsofgeneticpolymorphismofhlaantigensinacquiredaplasticanemiainchildren AT zmdishlevaya hecharacteristicsofgeneticpolymorphismofhlaantigensinacquiredaplasticanemiainchildren AT anarkhipova hecharacteristicsofgeneticpolymorphismofhlaantigensinacquiredaplasticanemiainchildren AT mmazova hecharacteristicsofgeneticpolymorphismofhlaantigensinacquiredaplasticanemiainchildren |
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1725322073133285376 |