Zika virus exposure affects neuron-glia communication in the hippocampal slices of adult rats
Abstract Zika virus (ZIKV) infection during pregnancy was associated with microcephaly in neonates, but clinical and experimental evidence indicate that ZIKV also causes neurological complications in adults. However, the changes in neuron-glial communication, which is essential for brain homeostasis...
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Nature Publishing Group
2020-12-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-78735-y |
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doaj-7355227ebb4649638543ccf12321e6ad |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Larissa Daniele Bobermin André Quincozes-Santos Camila Leite Santos Ana Paula M. Varela Thais F. Teixeira Krista Minéia Wartchow Lílian Juliana Lissner Amanda da Silva Natalie K. Thomaz Lucélia Santi Walter O. Beys-da-Silva Paulo M. Roehe Patrícia Sesterheim Jorge A. Guimarães Carlos-Alberto Gonçalves Diogo Onofre Souza |
spellingShingle |
Larissa Daniele Bobermin André Quincozes-Santos Camila Leite Santos Ana Paula M. Varela Thais F. Teixeira Krista Minéia Wartchow Lílian Juliana Lissner Amanda da Silva Natalie K. Thomaz Lucélia Santi Walter O. Beys-da-Silva Paulo M. Roehe Patrícia Sesterheim Jorge A. Guimarães Carlos-Alberto Gonçalves Diogo Onofre Souza Zika virus exposure affects neuron-glia communication in the hippocampal slices of adult rats Scientific Reports |
author_facet |
Larissa Daniele Bobermin André Quincozes-Santos Camila Leite Santos Ana Paula M. Varela Thais F. Teixeira Krista Minéia Wartchow Lílian Juliana Lissner Amanda da Silva Natalie K. Thomaz Lucélia Santi Walter O. Beys-da-Silva Paulo M. Roehe Patrícia Sesterheim Jorge A. Guimarães Carlos-Alberto Gonçalves Diogo Onofre Souza |
author_sort |
Larissa Daniele Bobermin |
title |
Zika virus exposure affects neuron-glia communication in the hippocampal slices of adult rats |
title_short |
Zika virus exposure affects neuron-glia communication in the hippocampal slices of adult rats |
title_full |
Zika virus exposure affects neuron-glia communication in the hippocampal slices of adult rats |
title_fullStr |
Zika virus exposure affects neuron-glia communication in the hippocampal slices of adult rats |
title_full_unstemmed |
Zika virus exposure affects neuron-glia communication in the hippocampal slices of adult rats |
title_sort |
zika virus exposure affects neuron-glia communication in the hippocampal slices of adult rats |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2020-12-01 |
description |
Abstract Zika virus (ZIKV) infection during pregnancy was associated with microcephaly in neonates, but clinical and experimental evidence indicate that ZIKV also causes neurological complications in adults. However, the changes in neuron-glial communication, which is essential for brain homeostasis, are still unknown. Here, we report that hippocampal slices from adult rats exposed acutely to ZIKV showed significant cellular alterations regarding to redox homeostasis, inflammatory process, neurotrophic functions and molecular signalling pathways associated with neurons and glial cells. Our findings support the hypothesis that ZIKV is highly neurotropic and its infection readily induces an inflammatory response, characterized by an increased expression and/or release of pro-inflammatory cytokines. We also observed changes in neural parameters, such as adenosine receptor A2a expression, as well as in the release of brain-derived neurotrophic factor and neuron-specific enolase, indicating plasticity synaptic impairment/neuronal damage. In addition, ZIKV induced a glial commitment, with alterations in specific and functional parameters such as aquaporin 4 expression, S100B secretion and glutathione synthesis. ZIKV also induced p21 senescence-associated gene expression, indicating that ZIKV may induce early senescence. Taken together, our results indicate that ZIKV-induced neuroinflammation, involving nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor κB (NFκB) pathways, affects important aspects of neuron-glia communication. Therefore, although ZIKV infection is transient, long-term consequences might be associated with neurological and/or neurodegenerative diseases. |
url |
https://doi.org/10.1038/s41598-020-78735-y |
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doaj-7355227ebb4649638543ccf12321e6ad2020-12-13T12:34:41ZengNature Publishing GroupScientific Reports2045-23222020-12-0110111110.1038/s41598-020-78735-yZika virus exposure affects neuron-glia communication in the hippocampal slices of adult ratsLarissa Daniele Bobermin0André Quincozes-Santos1Camila Leite Santos2Ana Paula M. Varela3Thais F. Teixeira4Krista Minéia Wartchow5Lílian Juliana Lissner6Amanda da Silva7Natalie K. Thomaz8Lucélia Santi9Walter O. Beys-da-Silva10Paulo M. Roehe11Patrícia Sesterheim12Jorge A. Guimarães13Carlos-Alberto Gonçalves14Diogo Onofre Souza15Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do SulPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do SulPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do SulDepartamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do SulDepartamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do SulPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do SulPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do SulPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do SulPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do SulFaculdade de Farmácia, Universidade Federal do Rio Grande do SulFaculdade de Farmácia, Universidade Federal do Rio Grande do SulDepartamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do SulCentro de Cardiologia Experimental, Instituto de Cardiologia/Fundação Universitária de CardiologiaCentro de Pesquisa Experimental, Hospital de Clínicas de Porto AlegrePrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do SulPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do SulAbstract Zika virus (ZIKV) infection during pregnancy was associated with microcephaly in neonates, but clinical and experimental evidence indicate that ZIKV also causes neurological complications in adults. However, the changes in neuron-glial communication, which is essential for brain homeostasis, are still unknown. Here, we report that hippocampal slices from adult rats exposed acutely to ZIKV showed significant cellular alterations regarding to redox homeostasis, inflammatory process, neurotrophic functions and molecular signalling pathways associated with neurons and glial cells. Our findings support the hypothesis that ZIKV is highly neurotropic and its infection readily induces an inflammatory response, characterized by an increased expression and/or release of pro-inflammatory cytokines. We also observed changes in neural parameters, such as adenosine receptor A2a expression, as well as in the release of brain-derived neurotrophic factor and neuron-specific enolase, indicating plasticity synaptic impairment/neuronal damage. In addition, ZIKV induced a glial commitment, with alterations in specific and functional parameters such as aquaporin 4 expression, S100B secretion and glutathione synthesis. ZIKV also induced p21 senescence-associated gene expression, indicating that ZIKV may induce early senescence. Taken together, our results indicate that ZIKV-induced neuroinflammation, involving nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor κB (NFκB) pathways, affects important aspects of neuron-glia communication. Therefore, although ZIKV infection is transient, long-term consequences might be associated with neurological and/or neurodegenerative diseases.https://doi.org/10.1038/s41598-020-78735-y |