Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice
<p>Abstract</p> <p>Background</p> <p>Proteolytic degradation has emerged as a key pathway involved in controlling levels of the Alzheimer's disease (AD)-associated amyloid-β (Aβ) peptide in the brain. The endopeptidase, neprilysin, has been implicated as a major Aβ...
Main Authors: | Patrick Christina, Potkar Rewati, Adame Anthony, Crews Leslie, Rockenstein Edward, Marr Robert A, Spencer Brian, Gage Fred H, Verma Inder M, Masliah Eliezer |
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Format: | Article |
Language: | English |
Published: |
BMC
2008-11-01
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Series: | BMC Neuroscience |
Online Access: | http://www.biomedcentral.com/1471-2202/9/109 |
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