Effectiveness of A(H1N1)pdm09 influenza vaccine in adults recommended for annual influenza vaccination.
INTRODUCTION: Because of variability in published A(H1N1)pdm09 influenza vaccine effectiveness estimates, we conducted a study in the adults belonging to the risk groups to assess the A(H1N1)pdm09 MF59-adjuvanted influenza vaccine effectiveness. METHODS: VE against influenza and/or pneumonia was ass...
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doaj-73579a8da4ce4fa4acfdfcbb3b1088682020-11-25T01:23:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0186e6612510.1371/journal.pone.0066125Effectiveness of A(H1N1)pdm09 influenza vaccine in adults recommended for annual influenza vaccination.Giedre GefenaiteMargot TackenJens BosIrina Stirbu-WagnerJoke C KorevaarRonald P StolkBert WoltersMarc BijlMaarten J PostmaJan WilschutKristin L NicholEelko HakINTRODUCTION: Because of variability in published A(H1N1)pdm09 influenza vaccine effectiveness estimates, we conducted a study in the adults belonging to the risk groups to assess the A(H1N1)pdm09 MF59-adjuvanted influenza vaccine effectiveness. METHODS: VE against influenza and/or pneumonia was assessed in the cohort study (n>25000), and vaccine effectiveness against laboratory-confirmed A(H1N1)pdm09 influenza was assessed in a matched case-control study (16 pairs). Odds ratios (OR) and their 95% confidence intervals (95% CI) were calculated by using multivariate logistic regression; vaccine effectiveness was estimated as (1-odds ratio)*100%. RESULTS: Vaccine effectiveness against laboratory-confirmed A(H1N1)pdm09 influenza and influenza and/or pneumonia was 98% (84-100%) and 33% (2-54%) respectively. The vaccine did not prevent influenza and/or pneumonia in 18-59 years old subjects, and was 49% (16-69%) effective in 60 years and older subjects. CONCLUSIONS: Even though we cannot entirely rule out that selection bias, residual confounding and/or cross-protection has played a role, the present results indicate that the MF59-adjuvanted A(H1N1)pdm09 influenza vaccine has been effective in preventing laboratory-confirmed A(H1N1)pdm09 influenza and influenza and/or pneumonia, the latter notably in 60 years and older subjects.http://europepmc.org/articles/PMC3688717?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giedre Gefenaite Margot Tacken Jens Bos Irina Stirbu-Wagner Joke C Korevaar Ronald P Stolk Bert Wolters Marc Bijl Maarten J Postma Jan Wilschut Kristin L Nichol Eelko Hak |
spellingShingle |
Giedre Gefenaite Margot Tacken Jens Bos Irina Stirbu-Wagner Joke C Korevaar Ronald P Stolk Bert Wolters Marc Bijl Maarten J Postma Jan Wilschut Kristin L Nichol Eelko Hak Effectiveness of A(H1N1)pdm09 influenza vaccine in adults recommended for annual influenza vaccination. PLoS ONE |
author_facet |
Giedre Gefenaite Margot Tacken Jens Bos Irina Stirbu-Wagner Joke C Korevaar Ronald P Stolk Bert Wolters Marc Bijl Maarten J Postma Jan Wilschut Kristin L Nichol Eelko Hak |
author_sort |
Giedre Gefenaite |
title |
Effectiveness of A(H1N1)pdm09 influenza vaccine in adults recommended for annual influenza vaccination. |
title_short |
Effectiveness of A(H1N1)pdm09 influenza vaccine in adults recommended for annual influenza vaccination. |
title_full |
Effectiveness of A(H1N1)pdm09 influenza vaccine in adults recommended for annual influenza vaccination. |
title_fullStr |
Effectiveness of A(H1N1)pdm09 influenza vaccine in adults recommended for annual influenza vaccination. |
title_full_unstemmed |
Effectiveness of A(H1N1)pdm09 influenza vaccine in adults recommended for annual influenza vaccination. |
title_sort |
effectiveness of a(h1n1)pdm09 influenza vaccine in adults recommended for annual influenza vaccination. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
INTRODUCTION: Because of variability in published A(H1N1)pdm09 influenza vaccine effectiveness estimates, we conducted a study in the adults belonging to the risk groups to assess the A(H1N1)pdm09 MF59-adjuvanted influenza vaccine effectiveness. METHODS: VE against influenza and/or pneumonia was assessed in the cohort study (n>25000), and vaccine effectiveness against laboratory-confirmed A(H1N1)pdm09 influenza was assessed in a matched case-control study (16 pairs). Odds ratios (OR) and their 95% confidence intervals (95% CI) were calculated by using multivariate logistic regression; vaccine effectiveness was estimated as (1-odds ratio)*100%. RESULTS: Vaccine effectiveness against laboratory-confirmed A(H1N1)pdm09 influenza and influenza and/or pneumonia was 98% (84-100%) and 33% (2-54%) respectively. The vaccine did not prevent influenza and/or pneumonia in 18-59 years old subjects, and was 49% (16-69%) effective in 60 years and older subjects. CONCLUSIONS: Even though we cannot entirely rule out that selection bias, residual confounding and/or cross-protection has played a role, the present results indicate that the MF59-adjuvanted A(H1N1)pdm09 influenza vaccine has been effective in preventing laboratory-confirmed A(H1N1)pdm09 influenza and influenza and/or pneumonia, the latter notably in 60 years and older subjects. |
url |
http://europepmc.org/articles/PMC3688717?pdf=render |
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