X-ray Phase-Contrast Computed Tomography for Soft Tissue Imaging at the Imaging and Medical Beamline (IMBL) of the Australian Synchrotron
The Imaging and Medical Beamline (IMBL) is a superconducting multipole wiggler-based beamline at the 3 GeV Australian Synchrotron operated by the Australian Nuclear Science and Technology Organisation (ANSTO). The beamline delivers hard X-rays in the 25–120 keV energy range and offers the potential...
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doaj-735a646eb9c846d1bdc0a519509f83292021-04-30T23:03:16ZengMDPI AGApplied Sciences2076-34172021-04-01114120412010.3390/app11094120X-ray Phase-Contrast Computed Tomography for Soft Tissue Imaging at the Imaging and Medical Beamline (IMBL) of the Australian SynchrotronBenedicta D. Arhatari0Andrew W. Stevenson1Brian Abbey2Yakov I. Nesterets3Anton Maksimenko4Christopher J. Hall5Darren Thompson6Sheridan C. Mayo7Tom Fiala8Harry M. Quiney9Seyedamir T. Taba10Sarah J. Lewis11Patrick C. Brennan12Matthew Dimmock13Daniel Häusermann14Timur E. Gureyev15Australian Synchrotron, ANSTO, Clayton, VIC 3168, AustraliaAustralian Synchrotron, ANSTO, Clayton, VIC 3168, AustraliaDepartment of Chemistry and Physics, La Trobe University, Bundoora, VIC 3086, AustraliaCSIRO, Clayton, VIC 3168, AustraliaAustralian Synchrotron, ANSTO, Clayton, VIC 3168, AustraliaAustralian Synchrotron, ANSTO, Clayton, VIC 3168, AustraliaCSIRO, Clayton, VIC 3168, AustraliaCSIRO, Clayton, VIC 3168, AustraliaAustralian Synchrotron, ANSTO, Clayton, VIC 3168, AustraliaSchool of Physics, The University of Melbourne, Parkville, VIC 3010, AustraliaFaculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, AustraliaFaculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, AustraliaFaculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, AustraliaMedical Imaging & Radiation Sciences, Monash University, Clayton, VIC 3168, AustraliaAustralian Synchrotron, ANSTO, Clayton, VIC 3168, AustraliaSchool of Physics, The University of Melbourne, Parkville, VIC 3010, AustraliaThe Imaging and Medical Beamline (IMBL) is a superconducting multipole wiggler-based beamline at the 3 GeV Australian Synchrotron operated by the Australian Nuclear Science and Technology Organisation (ANSTO). The beamline delivers hard X-rays in the 25–120 keV energy range and offers the potential for a range of biomedical X-ray applications, including radiotherapy and medical imaging experiments. One of the imaging modalities available at IMBL is propagation-based X-ray phase-contrast computed tomography (PCT). PCT produces superior results when imaging low-density materials such as soft tissue (e.g., breast mastectomies) and has the potential to be developed into a valuable medical imaging tool. We anticipate that PCT will be utilized for medical breast imaging in the near future with the advantage that it could provide better contrast than conventional X-ray absorption imaging. The unique properties of synchrotron X-ray sources such as high coherence, energy tunability, and high brightness are particularly well-suited for generating PCT data using very short exposure times on the order of less than 1 min. The coherence of synchrotron radiation allows for phase-contrast imaging with superior sensitivity to small differences in soft-tissue density. Here we also compare the results of PCT using two different detectors, as these unique source characteristics need to be complemented with a highly efficient detector. Moreover, the application of phase retrieval for PCT image reconstruction enables the use of noisier images, potentially significantly reducing the total dose received by patients during acquisition. This work is part of ongoing research into innovative tomographic methods aimed at the introduction of 3D X-ray medical imaging at the IMBL to improve the detection and diagnosis of breast cancer. Major progress in this area at the IMBL includes the characterization of a large number of mastectomy samples, both normal and cancerous, which have been scanned at clinically acceptable radiation dose levels and evaluated by expert radiologists with respect to both image quality and cancer diagnosis.https://www.mdpi.com/2076-3417/11/9/4120phase-contrastcomputed tomographysoft-tissue imagingsynchrotron |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Benedicta D. Arhatari Andrew W. Stevenson Brian Abbey Yakov I. Nesterets Anton Maksimenko Christopher J. Hall Darren Thompson Sheridan C. Mayo Tom Fiala Harry M. Quiney Seyedamir T. Taba Sarah J. Lewis Patrick C. Brennan Matthew Dimmock Daniel Häusermann Timur E. Gureyev |
spellingShingle |
Benedicta D. Arhatari Andrew W. Stevenson Brian Abbey Yakov I. Nesterets Anton Maksimenko Christopher J. Hall Darren Thompson Sheridan C. Mayo Tom Fiala Harry M. Quiney Seyedamir T. Taba Sarah J. Lewis Patrick C. Brennan Matthew Dimmock Daniel Häusermann Timur E. Gureyev X-ray Phase-Contrast Computed Tomography for Soft Tissue Imaging at the Imaging and Medical Beamline (IMBL) of the Australian Synchrotron Applied Sciences phase-contrast computed tomography soft-tissue imaging synchrotron |
author_facet |
Benedicta D. Arhatari Andrew W. Stevenson Brian Abbey Yakov I. Nesterets Anton Maksimenko Christopher J. Hall Darren Thompson Sheridan C. Mayo Tom Fiala Harry M. Quiney Seyedamir T. Taba Sarah J. Lewis Patrick C. Brennan Matthew Dimmock Daniel Häusermann Timur E. Gureyev |
author_sort |
Benedicta D. Arhatari |
title |
X-ray Phase-Contrast Computed Tomography for Soft Tissue Imaging at the Imaging and Medical Beamline (IMBL) of the Australian Synchrotron |
title_short |
X-ray Phase-Contrast Computed Tomography for Soft Tissue Imaging at the Imaging and Medical Beamline (IMBL) of the Australian Synchrotron |
title_full |
X-ray Phase-Contrast Computed Tomography for Soft Tissue Imaging at the Imaging and Medical Beamline (IMBL) of the Australian Synchrotron |
title_fullStr |
X-ray Phase-Contrast Computed Tomography for Soft Tissue Imaging at the Imaging and Medical Beamline (IMBL) of the Australian Synchrotron |
title_full_unstemmed |
X-ray Phase-Contrast Computed Tomography for Soft Tissue Imaging at the Imaging and Medical Beamline (IMBL) of the Australian Synchrotron |
title_sort |
x-ray phase-contrast computed tomography for soft tissue imaging at the imaging and medical beamline (imbl) of the australian synchrotron |
publisher |
MDPI AG |
series |
Applied Sciences |
issn |
2076-3417 |
publishDate |
2021-04-01 |
description |
The Imaging and Medical Beamline (IMBL) is a superconducting multipole wiggler-based beamline at the 3 GeV Australian Synchrotron operated by the Australian Nuclear Science and Technology Organisation (ANSTO). The beamline delivers hard X-rays in the 25–120 keV energy range and offers the potential for a range of biomedical X-ray applications, including radiotherapy and medical imaging experiments. One of the imaging modalities available at IMBL is propagation-based X-ray phase-contrast computed tomography (PCT). PCT produces superior results when imaging low-density materials such as soft tissue (e.g., breast mastectomies) and has the potential to be developed into a valuable medical imaging tool. We anticipate that PCT will be utilized for medical breast imaging in the near future with the advantage that it could provide better contrast than conventional X-ray absorption imaging. The unique properties of synchrotron X-ray sources such as high coherence, energy tunability, and high brightness are particularly well-suited for generating PCT data using very short exposure times on the order of less than 1 min. The coherence of synchrotron radiation allows for phase-contrast imaging with superior sensitivity to small differences in soft-tissue density. Here we also compare the results of PCT using two different detectors, as these unique source characteristics need to be complemented with a highly efficient detector. Moreover, the application of phase retrieval for PCT image reconstruction enables the use of noisier images, potentially significantly reducing the total dose received by patients during acquisition. This work is part of ongoing research into innovative tomographic methods aimed at the introduction of 3D X-ray medical imaging at the IMBL to improve the detection and diagnosis of breast cancer. Major progress in this area at the IMBL includes the characterization of a large number of mastectomy samples, both normal and cancerous, which have been scanned at clinically acceptable radiation dose levels and evaluated by expert radiologists with respect to both image quality and cancer diagnosis. |
topic |
phase-contrast computed tomography soft-tissue imaging synchrotron |
url |
https://www.mdpi.com/2076-3417/11/9/4120 |
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