Design of experiment avenue for development and validation of RP-HPLC-PDA method for determination of apremilast in bulk and in in-house tablet formulation

Design of experiment avenue for development and validation of RP-HPLC-PDA method for determination of apremilast in bulk and in in-house tablet formulation

Abstract Background Apremilast is phosphodiesterase-4 and an immunomodulating agent used for treatment of refractory psoriatic arthritis. Methods The reversed-phase high-performance liquid-chromatography method for analysis of apremilast was developed and validated as per ICH guidelines. The separat...

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Bibliographic Details
Main Authors: Suraj R. Chaudhari, Atul A. Shirkhedkar
Format: Article
Language:English
Published: SpringerOpen 2019-02-01
Series:Journal of Analytical Science and Technology
Subjects:
Apremilast
HPLC
in-house tablets
Box–Behnken design
Validation
Online Access:http://link.springer.com/article/10.1186/s40543-019-0170-8

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