Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission

Lysophosphatidylcholine is a bioactive lipid that regulates a large number of cellular processes and is especially present during the deposition and infiltration of inflammatory cells and deposition of atheromatous plaque. Such molecule is also present in saliva and feces of the hematophagous organi...

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Main Authors: Mário A. C. Silva-Neto, Alan B. Carneiro, Livia Silva-Cardoso, Georgia C. Atella
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Journal of Parasitology Research
Online Access:http://dx.doi.org/10.1155/2012/625838
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spelling doaj-738bd2bc80864505966aa1e880b4e7162020-11-24T23:23:06ZengHindawi LimitedJournal of Parasitology Research2090-00232090-00312012-01-01201210.1155/2012/625838625838Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi TransmissionMário A. C. Silva-Neto0Alan B. Carneiro1Livia Silva-Cardoso2Georgia C. Atella3Instituto de Bioquímica Médica at Universidade Federal do Rio de Janeiro (UFRJ), 21940-590 Rio de Janeiro, RJ, BrazilInstituto de Bioquímica Médica at Universidade Federal do Rio de Janeiro (UFRJ), 21940-590 Rio de Janeiro, RJ, BrazilInstituto de Bioquímica Médica at Universidade Federal do Rio de Janeiro (UFRJ), 21940-590 Rio de Janeiro, RJ, BrazilInstituto de Bioquímica Médica at Universidade Federal do Rio de Janeiro (UFRJ), 21940-590 Rio de Janeiro, RJ, BrazilLysophosphatidylcholine is a bioactive lipid that regulates a large number of cellular processes and is especially present during the deposition and infiltration of inflammatory cells and deposition of atheromatous plaque. Such molecule is also present in saliva and feces of the hematophagous organism Rhodnius prolixus, a triatominae bug vector of Chagas disease. We have recently demonstrated that LPC is a modulator of Trypanosoma cruzi transmission. It acts as a powerful chemoattractant for inflammatory cells at the site of the insect bite, which will provide a concentrated population of cells available for parasite infection. Also, LPC increases macrophage intracellular calcium concentrations that ultimately enhance parasite invasion. Finally, LPC inhibits NO production by macrophages stimulated by live T. cruzi, and thus interferes with the immune system of the vertebrate host. In the present paper, we discuss the main signaling mechanisms that are likely used by such molecule and their eventual use as targets to block parasite transmission and the pathogenesis of Chagas disease.http://dx.doi.org/10.1155/2012/625838
collection DOAJ
language English
format Article
sources DOAJ
author Mário A. C. Silva-Neto
Alan B. Carneiro
Livia Silva-Cardoso
Georgia C. Atella
spellingShingle Mário A. C. Silva-Neto
Alan B. Carneiro
Livia Silva-Cardoso
Georgia C. Atella
Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission
Journal of Parasitology Research
author_facet Mário A. C. Silva-Neto
Alan B. Carneiro
Livia Silva-Cardoso
Georgia C. Atella
author_sort Mário A. C. Silva-Neto
title Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission
title_short Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission
title_full Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission
title_fullStr Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission
title_full_unstemmed Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission
title_sort lysophosphatidylcholine: a novel modulator of trypanosoma cruzi transmission
publisher Hindawi Limited
series Journal of Parasitology Research
issn 2090-0023
2090-0031
publishDate 2012-01-01
description Lysophosphatidylcholine is a bioactive lipid that regulates a large number of cellular processes and is especially present during the deposition and infiltration of inflammatory cells and deposition of atheromatous plaque. Such molecule is also present in saliva and feces of the hematophagous organism Rhodnius prolixus, a triatominae bug vector of Chagas disease. We have recently demonstrated that LPC is a modulator of Trypanosoma cruzi transmission. It acts as a powerful chemoattractant for inflammatory cells at the site of the insect bite, which will provide a concentrated population of cells available for parasite infection. Also, LPC increases macrophage intracellular calcium concentrations that ultimately enhance parasite invasion. Finally, LPC inhibits NO production by macrophages stimulated by live T. cruzi, and thus interferes with the immune system of the vertebrate host. In the present paper, we discuss the main signaling mechanisms that are likely used by such molecule and their eventual use as targets to block parasite transmission and the pathogenesis of Chagas disease.
url http://dx.doi.org/10.1155/2012/625838
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AT liviasilvacardoso lysophosphatidylcholineanovelmodulatoroftrypanosomacruzitransmission
AT georgiacatella lysophosphatidylcholineanovelmodulatoroftrypanosomacruzitransmission
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