Peroxisomes and Innate Immunity: Antiviral Response and Beyond
Peroxisomes are ubiquitous organelles with well-defined functions in lipid and reactive oxygen species metabolism, having a significant impact on a large number of important diseases. Growing evidence points to them, in concert with mitochondria, as important players within the antiviral response. I...
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doaj-7391dd4db66349979c9006258226f9d72020-11-25T02:20:27ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-08-012015379510.3390/ijms20153795ijms20153795Peroxisomes and Innate Immunity: Antiviral Response and BeyondAna Rita Ferreira0Mariana Marques1Daniela Ribeiro2Institute of Biomedicine (iBiMED) & Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, PortugalInstitute of Biomedicine (iBiMED) & Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, PortugalInstitute of Biomedicine (iBiMED) & Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, PortugalPeroxisomes are ubiquitous organelles with well-defined functions in lipid and reactive oxygen species metabolism, having a significant impact on a large number of important diseases. Growing evidence points to them, in concert with mitochondria, as important players within the antiviral response. In this review we summarize and discuss the recent findings concerning the relevance of peroxisomes within innate immunity. We not only emphasize their importance as platforms for cellular antiviral signaling but also review the current information concerning their role in the control of bacterial infections. We furthermore review the recent data that pinpoints peroxisomes as regulators of inflammatory processes.https://www.mdpi.com/1422-0067/20/15/3795peroxisomesinnate immunityvirusesmitochondrial antiviral signaling protein (MAVS)signalingmicrobesbacteriainflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana Rita Ferreira Mariana Marques Daniela Ribeiro |
spellingShingle |
Ana Rita Ferreira Mariana Marques Daniela Ribeiro Peroxisomes and Innate Immunity: Antiviral Response and Beyond International Journal of Molecular Sciences peroxisomes innate immunity viruses mitochondrial antiviral signaling protein (MAVS) signaling microbes bacteria inflammation |
author_facet |
Ana Rita Ferreira Mariana Marques Daniela Ribeiro |
author_sort |
Ana Rita Ferreira |
title |
Peroxisomes and Innate Immunity: Antiviral Response and Beyond |
title_short |
Peroxisomes and Innate Immunity: Antiviral Response and Beyond |
title_full |
Peroxisomes and Innate Immunity: Antiviral Response and Beyond |
title_fullStr |
Peroxisomes and Innate Immunity: Antiviral Response and Beyond |
title_full_unstemmed |
Peroxisomes and Innate Immunity: Antiviral Response and Beyond |
title_sort |
peroxisomes and innate immunity: antiviral response and beyond |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-08-01 |
description |
Peroxisomes are ubiquitous organelles with well-defined functions in lipid and reactive oxygen species metabolism, having a significant impact on a large number of important diseases. Growing evidence points to them, in concert with mitochondria, as important players within the antiviral response. In this review we summarize and discuss the recent findings concerning the relevance of peroxisomes within innate immunity. We not only emphasize their importance as platforms for cellular antiviral signaling but also review the current information concerning their role in the control of bacterial infections. We furthermore review the recent data that pinpoints peroxisomes as regulators of inflammatory processes. |
topic |
peroxisomes innate immunity viruses mitochondrial antiviral signaling protein (MAVS) signaling microbes bacteria inflammation |
url |
https://www.mdpi.com/1422-0067/20/15/3795 |
work_keys_str_mv |
AT anaritaferreira peroxisomesandinnateimmunityantiviralresponseandbeyond AT marianamarques peroxisomesandinnateimmunityantiviralresponseandbeyond AT danielaribeiro peroxisomesandinnateimmunityantiviralresponseandbeyond |
_version_ |
1724871259943075840 |