Superparamagnetic Iron Oxide Nanoparticles Carrying Chemotherapeutics Improve Drug Efficacy in Monolayer and Spheroid Cell Culture by Enabling Active Accumulation

Superparamagnetic Iron Oxide Nanoparticles Carrying Chemotherapeutics Improve Drug Efficacy in Monolayer and Spheroid Cell Culture by Enabling Active Accumulation

Cytotoxic and cytostatic chemotherapeutics act by attacking rapidly dividing tumor cells, predominantly affecting malignant tissue and to a certain degree preserving healthy cells. Nonetheless, severe side effects are caused as quickly proliferating healthy cells such as hematopoietic precursors and...

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Bibliographic Details
Main Authors: Khanh Nguyen, Bianca Nuß, Marina Mühlberger, Harald Unterweger, Ralf P. Friedrich, Christoph Alexiou, Christina Janko
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Nanomaterials
Subjects:
tumor spheroids
superparamagnetic iron oxide nanoparticles
magnetic drug targeting
nanomedicine
chemotherapy
drug resistance
Online Access:https://www.mdpi.com/2079-4991/10/8/1577

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