Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations
Somatic and germline mutations are found at different densities across the genome. Here, the authors compare human somatic tumour mutations with the germline of humans, chimpanzees, and gorillas, and find that the mutation density of tumours correlates better with non-human great apes than with the...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-05-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16296-4 |
| Summary: | Somatic and germline mutations are found at different densities across the genome. Here, the authors compare human somatic tumour mutations with the germline of humans, chimpanzees, and gorillas, and find that the mutation density of tumours correlates better with non-human great apes than with the human germline. |
|---|---|
| ISSN: | 2041-1723 |