Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations

Somatic and germline mutations are found at different densities across the genome. Here, the authors compare human somatic tumour mutations with the germline of humans, chimpanzees, and gorillas, and find that the mutation density of tumours correlates better with non-human great apes than with the...

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Bibliographic Details
Main Authors: José María Heredia-Genestar, Tomàs Marquès-Bonet, David Juan, Arcadi Navarro
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16296-4