Heightened Salience of Anger and Aggression in Female Adolescents With Borderline Personality Disorder—A Script-Based fMRI Study
Background: Anger and aggression belong to the core symptoms of borderline personality disorder. Although an early and specific treatment of BPD is highly relevant to prevent chronification, still little is known about anger and aggression and their neural underpinnings in adolescents with BPD.Metho...
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doaj-73962b764dcc4bafa5be7c09d2eebf1a2020-11-24T22:55:06ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532018-03-011210.3389/fnbeh.2018.00057341143Heightened Salience of Anger and Aggression in Female Adolescents With Borderline Personality Disorder—A Script-Based fMRI StudyMarlene Krauch0Kai Ueltzhöffer1Kai Ueltzhöffer2Kai Ueltzhöffer3Romuald Brunner4Michael Kaess5Michael Kaess6Saskia Hensel7Sabine C. Herpertz8Katja Bertsch9Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Heidelberg, GermanyDepartment of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Heidelberg, GermanyDepartment of Psychology, Goethe University Frankfurt, Frankfurt am Main, GermanyBernstein Center for Computational Neuroscience, University of Heidelberg, Mannheim, GermanyDepartment of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Heidelberg, GermanyDepartment of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Heidelberg, GermanyUniversity Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, SwitzerlandDepartment of Psychosomatic Medicine, Central Institute of Mental Health, Mannheim, GermanyDepartment of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Heidelberg, GermanyDepartment of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Heidelberg, GermanyBackground: Anger and aggression belong to the core symptoms of borderline personality disorder. Although an early and specific treatment of BPD is highly relevant to prevent chronification, still little is known about anger and aggression and their neural underpinnings in adolescents with BPD.Method: Twenty female adolescents with BPD (age 15–17 years) and 20 female healthy adolescents (age 15–17 years) took part in this functional magnetic resonance imaging (fMRI) study. A script-driven imagery paradigm was used to induce rejection-based feelings of anger, which was followed by descriptions of self-directed and other-directed aggressive reactions. To investigate the specificity of the neural activation patterns for adolescent patients, results were compared with data from 34 female adults with BPD (age 18–50 years) and 32 female healthy adults (age 18–50 years).Results: Adolescents with BPD showed increased activations in the left posterior insula and left dorsal striatum as well as in the left inferior frontal cortex and parts of the mentalizing network during the rejection-based anger induction and the imagination of aggressive reactions compared to healthy adolescents. For the other-directed aggression phase, a significant diagnosis by age interaction confirmed that these results were specific for adolescents.Discussion: The results of this very first fMRI study on anger and aggression in adolescents with BPD suggest an enhanced emotional reactivity to and higher effort in controlling anger and aggression evoked by social rejection at an early developmental stage of the disorder. Since emotion dysregulation is a known mediator for aggression in BPD, the results point to the need of appropriate early interventions for adolescents with BPD.http://journal.frontiersin.org/article/10.3389/fnbeh.2018.00057/fullangeraggressionemotion regulationborderline personality disorderadolescencesocial threat sensitivity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marlene Krauch Kai Ueltzhöffer Kai Ueltzhöffer Kai Ueltzhöffer Romuald Brunner Michael Kaess Michael Kaess Saskia Hensel Sabine C. Herpertz Katja Bertsch |
spellingShingle |
Marlene Krauch Kai Ueltzhöffer Kai Ueltzhöffer Kai Ueltzhöffer Romuald Brunner Michael Kaess Michael Kaess Saskia Hensel Sabine C. Herpertz Katja Bertsch Heightened Salience of Anger and Aggression in Female Adolescents With Borderline Personality Disorder—A Script-Based fMRI Study Frontiers in Behavioral Neuroscience anger aggression emotion regulation borderline personality disorder adolescence social threat sensitivity |
author_facet |
Marlene Krauch Kai Ueltzhöffer Kai Ueltzhöffer Kai Ueltzhöffer Romuald Brunner Michael Kaess Michael Kaess Saskia Hensel Sabine C. Herpertz Katja Bertsch |
author_sort |
Marlene Krauch |
title |
Heightened Salience of Anger and Aggression in Female Adolescents With Borderline Personality Disorder—A Script-Based fMRI Study |
title_short |
Heightened Salience of Anger and Aggression in Female Adolescents With Borderline Personality Disorder—A Script-Based fMRI Study |
title_full |
Heightened Salience of Anger and Aggression in Female Adolescents With Borderline Personality Disorder—A Script-Based fMRI Study |
title_fullStr |
Heightened Salience of Anger and Aggression in Female Adolescents With Borderline Personality Disorder—A Script-Based fMRI Study |
title_full_unstemmed |
Heightened Salience of Anger and Aggression in Female Adolescents With Borderline Personality Disorder—A Script-Based fMRI Study |
title_sort |
heightened salience of anger and aggression in female adolescents with borderline personality disorder—a script-based fmri study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Behavioral Neuroscience |
issn |
1662-5153 |
publishDate |
2018-03-01 |
description |
Background: Anger and aggression belong to the core symptoms of borderline personality disorder. Although an early and specific treatment of BPD is highly relevant to prevent chronification, still little is known about anger and aggression and their neural underpinnings in adolescents with BPD.Method: Twenty female adolescents with BPD (age 15–17 years) and 20 female healthy adolescents (age 15–17 years) took part in this functional magnetic resonance imaging (fMRI) study. A script-driven imagery paradigm was used to induce rejection-based feelings of anger, which was followed by descriptions of self-directed and other-directed aggressive reactions. To investigate the specificity of the neural activation patterns for adolescent patients, results were compared with data from 34 female adults with BPD (age 18–50 years) and 32 female healthy adults (age 18–50 years).Results: Adolescents with BPD showed increased activations in the left posterior insula and left dorsal striatum as well as in the left inferior frontal cortex and parts of the mentalizing network during the rejection-based anger induction and the imagination of aggressive reactions compared to healthy adolescents. For the other-directed aggression phase, a significant diagnosis by age interaction confirmed that these results were specific for adolescents.Discussion: The results of this very first fMRI study on anger and aggression in adolescents with BPD suggest an enhanced emotional reactivity to and higher effort in controlling anger and aggression evoked by social rejection at an early developmental stage of the disorder. Since emotion dysregulation is a known mediator for aggression in BPD, the results point to the need of appropriate early interventions for adolescents with BPD. |
topic |
anger aggression emotion regulation borderline personality disorder adolescence social threat sensitivity |
url |
http://journal.frontiersin.org/article/10.3389/fnbeh.2018.00057/full |
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