Antidiabetic activities of ethanol extract of dry matters of culture broth of Coriolus versiolor in submerged culture
The study aimed to investigate the antihyperglycemic and antilipidperoxidative effects of ethanol extract of the dry matter from culture broth of Coriolus versicolor (ECBC) in streptozotocin-induced diabetes mice. Blood glucose level, insulin level, total cholesterol (TC), triglyceride (TG), low den...
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Instituto de Tecnologia do Paraná (Tecpar)
2011-08-01
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doaj-7396ca09ae3b4cab89c4171d9c5cc4c02020-11-24T22:15:42ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1516-89131678-43242011-08-0154470170810.1590/S1516-89132011000400008Antidiabetic activities of ethanol extract of dry matters of culture broth of Coriolus versiolor in submerged cultureZuofa ZhangGuoying LvHuijuan PanLeandro Freire dos SantosMenghai FanCarlos Ricardo SoccolVanete Thomaz-SoccolLuiz Gustavo LacerdaMarco Aurélio da Silva Carvalho FilhoLeifa FanThe study aimed to investigate the antihyperglycemic and antilipidperoxidative effects of ethanol extract of the dry matter from culture broth of Coriolus versicolor (ECBC) in streptozotocin-induced diabetes mice. Blood glucose level, insulin level, total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol(LDL-C), high density lipoprotein -cholesterol (HDL-C) in serum and reduced glutathione level (GSH), lipid peroxidation, glycogen, antioxidant enzymes in liver were evaluated. Moreover, histopathological observation was conducted. Streptozotocin treatment (150 mg/kg body weight) induced the decrease of GSH level, antioxidant enzymes activities, glycogen content in liver, HDL-C content and insulin level in serum, accompanied by the elevation of the lipid peroxidation in liver, serum blood glucose level, contents of TC, TG and LDL-C. Treatment with ECBC restored the changes in the above parameters up to the basal level. The protective effects were further supported by the attenuation of the degree of pancreas damage in ECBC treated mice.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000400008Coriolus versiolorAntihyperglycemicAntilipidperoxidativeDiabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zuofa Zhang Guoying Lv Huijuan Pan Leandro Freire dos Santos Menghai Fan Carlos Ricardo Soccol Vanete Thomaz-Soccol Luiz Gustavo Lacerda Marco Aurélio da Silva Carvalho Filho Leifa Fan |
spellingShingle |
Zuofa Zhang Guoying Lv Huijuan Pan Leandro Freire dos Santos Menghai Fan Carlos Ricardo Soccol Vanete Thomaz-Soccol Luiz Gustavo Lacerda Marco Aurélio da Silva Carvalho Filho Leifa Fan Antidiabetic activities of ethanol extract of dry matters of culture broth of Coriolus versiolor in submerged culture Brazilian Archives of Biology and Technology Coriolus versiolor Antihyperglycemic Antilipidperoxidative Diabetes |
author_facet |
Zuofa Zhang Guoying Lv Huijuan Pan Leandro Freire dos Santos Menghai Fan Carlos Ricardo Soccol Vanete Thomaz-Soccol Luiz Gustavo Lacerda Marco Aurélio da Silva Carvalho Filho Leifa Fan |
author_sort |
Zuofa Zhang |
title |
Antidiabetic activities of ethanol extract of dry matters of culture broth of Coriolus versiolor in submerged culture |
title_short |
Antidiabetic activities of ethanol extract of dry matters of culture broth of Coriolus versiolor in submerged culture |
title_full |
Antidiabetic activities of ethanol extract of dry matters of culture broth of Coriolus versiolor in submerged culture |
title_fullStr |
Antidiabetic activities of ethanol extract of dry matters of culture broth of Coriolus versiolor in submerged culture |
title_full_unstemmed |
Antidiabetic activities of ethanol extract of dry matters of culture broth of Coriolus versiolor in submerged culture |
title_sort |
antidiabetic activities of ethanol extract of dry matters of culture broth of coriolus versiolor in submerged culture |
publisher |
Instituto de Tecnologia do Paraná (Tecpar) |
series |
Brazilian Archives of Biology and Technology |
issn |
1516-8913 1678-4324 |
publishDate |
2011-08-01 |
description |
The study aimed to investigate the antihyperglycemic and antilipidperoxidative effects of ethanol extract of the dry matter from culture broth of Coriolus versicolor (ECBC) in streptozotocin-induced diabetes mice. Blood glucose level, insulin level, total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol(LDL-C), high density lipoprotein -cholesterol (HDL-C) in serum and reduced glutathione level (GSH), lipid peroxidation, glycogen, antioxidant enzymes in liver were evaluated. Moreover, histopathological observation was conducted. Streptozotocin treatment (150 mg/kg body weight) induced the decrease of GSH level, antioxidant enzymes activities, glycogen content in liver, HDL-C content and insulin level in serum, accompanied by the elevation of the lipid peroxidation in liver, serum blood glucose level, contents of TC, TG and LDL-C. Treatment with ECBC restored the changes in the above parameters up to the basal level. The protective effects were further supported by the attenuation of the degree of pancreas damage in ECBC treated mice. |
topic |
Coriolus versiolor Antihyperglycemic Antilipidperoxidative Diabetes |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000400008 |
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