Aberrant Promoter Hypermethylation of RASSF Family Members in Merkel Cell Carcinoma

Aberrant Promoter Hypermethylation of RASSF Family Members in Merkel Cell Carcinoma

Merkel cell carcinoma (MCC) is one of the most aggressive cancers of the skin. RASSFs are a family of tumor suppressors that are frequently inactivated by promoter hypermethylation in various cancers. We studied CpG island promoter hypermethylation in MCC of RASSF2, RASSF5A, RASSF5C and RASSF10 by c...

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Bibliographic Details
Main Authors: Antje M. Richter, Tanja Haag, Sara Walesch, Peter Herrmann-Trost, Wolfgang C. Marsch, Heinz Kutzner, Peter Helmbold, Reinhard H. Dammann
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:Cancers
Subjects:
merkel cell
tumor suppressor
DNA methylation
epigenetics
RASSF
Online Access:http://www.mdpi.com/2072-6694/5/4/1566

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