PATHOGENETIC ASPECTS OF ATHEROTHOMBOTIC RISK IN OBESITY AND THROMBOPHILIA

PATHOGENETIC ASPECTS OF ATHEROTHOMBOTIC RISK IN OBESITY AND THROMBOPHILIA

The assosiation between obesity, cardiovascular diseases and thrombosis is well-known and is caused by proinflammatory and prothombotic status in obesity. Numerous hormones and cytokines, secreted by adipocytes, influence the gene expression and function of endothelial cells, arterial smooth muscle...

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Main Author: A. V. Khromylev
Format: Article
Language:Russian
Published: IRBIS LLC 2016-06-01
Series:Акушерство, гинекология и репродукция
Subjects:
metabolic syndrome
obesity
thromboembolic complications
thrombosis
thrombophilia
Online Access:https://www.gynecology.su/jour/article/view/172
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spelling doaj-739f94c912b14f10ac3033ec7fd54bb42021-07-28T13:44:38ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942016-06-0193455210.17749/2070-4968.2015.9.3.045-052170PATHOGENETIC ASPECTS OF ATHEROTHOMBOTIC RISK IN OBESITY AND THROMBOPHILIAA. V. Khromylev0First Moscow State Medical Sechenov UniversityThe assosiation between obesity, cardiovascular diseases and thrombosis is well-known and is caused by proinflammatory and prothombotic status in obesity. Numerous hormones and cytokines, secreted by adipocytes, influence the gene expression and function of endothelial cells, arterial smooth muscle cells, and monocytes leading to the development of an atherosclerotic plaque. Also, variety of cytokines produced by adipocytes controls endothelial function, hemostatic and fibrinolytic systems, platelet function, affecting progression of thombus formation. Nowadays,pathogenetic mechanisms of this relationship are under active study. Thrombophilia is another independent risk factor of tromboembolic complications.https://www.gynecology.su/jour/article/view/172metabolic syndromeobesitythromboembolic complicationsthrombosisthrombophilia
collection DOAJ
language Russian
format Article
sources DOAJ
author A. V. Khromylev
spellingShingle A. V. Khromylev
PATHOGENETIC ASPECTS OF ATHEROTHOMBOTIC RISK IN OBESITY AND THROMBOPHILIA
Акушерство, гинекология и репродукция
metabolic syndrome
obesity
thromboembolic complications
thrombosis
thrombophilia
author_facet A. V. Khromylev
author_sort A. V. Khromylev
title PATHOGENETIC ASPECTS OF ATHEROTHOMBOTIC RISK IN OBESITY AND THROMBOPHILIA
title_short PATHOGENETIC ASPECTS OF ATHEROTHOMBOTIC RISK IN OBESITY AND THROMBOPHILIA
title_full PATHOGENETIC ASPECTS OF ATHEROTHOMBOTIC RISK IN OBESITY AND THROMBOPHILIA
title_fullStr PATHOGENETIC ASPECTS OF ATHEROTHOMBOTIC RISK IN OBESITY AND THROMBOPHILIA
title_full_unstemmed PATHOGENETIC ASPECTS OF ATHEROTHOMBOTIC RISK IN OBESITY AND THROMBOPHILIA
title_sort pathogenetic aspects of atherothombotic risk in obesity and thrombophilia
publisher IRBIS LLC
series Акушерство, гинекология и репродукция
issn 2313-7347
2500-3194
publishDate 2016-06-01
description The assosiation between obesity, cardiovascular diseases and thrombosis is well-known and is caused by proinflammatory and prothombotic status in obesity. Numerous hormones and cytokines, secreted by adipocytes, influence the gene expression and function of endothelial cells, arterial smooth muscle cells, and monocytes leading to the development of an atherosclerotic plaque. Also, variety of cytokines produced by adipocytes controls endothelial function, hemostatic and fibrinolytic systems, platelet function, affecting progression of thombus formation. Nowadays,pathogenetic mechanisms of this relationship are under active study. Thrombophilia is another independent risk factor of tromboembolic complications.
topic metabolic syndrome
obesity
thromboembolic complications
thrombosis
thrombophilia
url https://www.gynecology.su/jour/article/view/172
work_keys_str_mv AT avkhromylev pathogeneticaspectsofatherothomboticriskinobesityandthrombophilia
_version_ 1721272100355833856

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