Clinical issues of mucus accumulation in COPD
Frederick L Ramos, Jason S Krahnke, Victor KimDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USAAbstract: Airway mucus is part of the lung's native immune function that traps particulates and microorganisms,...
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doaj-73ad397b1330484fa652cee16412e4582020-11-25T01:22:47ZengDove Medical PressInternational Journal of COPD1178-20052014-01-012014default13915015626Clinical issues of mucus accumulation in COPDRamos FLKrahnke JSKim V Frederick L Ramos, Jason S Krahnke, Victor KimDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USAAbstract: Airway mucus is part of the lung's native immune function that traps particulates and microorganisms, enabling their clearance from the lung by ciliary transport and cough. Mucus hypersecretion and chronic productive cough are the features of the chronic bronchitis and chronic obstructive pulmonary disease (COPD). Overproduction and hypersecretion by goblet cells and the decreased elimination of mucus are the primary mechanisms responsible for excessive mucus in chronic bronchitis. Mucus accumulation in COPD patients affects several important outcomes such as lung function, health-related quality of life, COPD exacerbations, hospitalizations, and mortality. Nonpharmacologic options for the treatment of mucus accumulation in COPD are smoking cessation and physical measures used to promote mucus clearance. Pharmacologic therapies include expectorants, mucolytics, methylxanthines, beta-adrenergic receptor agonists, anticholinergics, glucocorticoids, phosphodiesterase-4 inhibitors, antioxidants, and antibiotics.Keywords: chronic obstructive pulmonary disease, chronic bronchitis, mucus, sputumhttp://www.dovepress.com/clinical-issues-of-mucus-accumulation-in-copd-a15626 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ramos FL Krahnke JS Kim V |
spellingShingle |
Ramos FL Krahnke JS Kim V Clinical issues of mucus accumulation in COPD International Journal of COPD |
author_facet |
Ramos FL Krahnke JS Kim V |
author_sort |
Ramos FL |
title |
Clinical issues of mucus accumulation in COPD |
title_short |
Clinical issues of mucus accumulation in COPD |
title_full |
Clinical issues of mucus accumulation in COPD |
title_fullStr |
Clinical issues of mucus accumulation in COPD |
title_full_unstemmed |
Clinical issues of mucus accumulation in COPD |
title_sort |
clinical issues of mucus accumulation in copd |
publisher |
Dove Medical Press |
series |
International Journal of COPD |
issn |
1178-2005 |
publishDate |
2014-01-01 |
description |
Frederick L Ramos, Jason S Krahnke, Victor KimDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USAAbstract: Airway mucus is part of the lung's native immune function that traps particulates and microorganisms, enabling their clearance from the lung by ciliary transport and cough. Mucus hypersecretion and chronic productive cough are the features of the chronic bronchitis and chronic obstructive pulmonary disease (COPD). Overproduction and hypersecretion by goblet cells and the decreased elimination of mucus are the primary mechanisms responsible for excessive mucus in chronic bronchitis. Mucus accumulation in COPD patients affects several important outcomes such as lung function, health-related quality of life, COPD exacerbations, hospitalizations, and mortality. Nonpharmacologic options for the treatment of mucus accumulation in COPD are smoking cessation and physical measures used to promote mucus clearance. Pharmacologic therapies include expectorants, mucolytics, methylxanthines, beta-adrenergic receptor agonists, anticholinergics, glucocorticoids, phosphodiesterase-4 inhibitors, antioxidants, and antibiotics.Keywords: chronic obstructive pulmonary disease, chronic bronchitis, mucus, sputum |
url |
http://www.dovepress.com/clinical-issues-of-mucus-accumulation-in-copd-a15626 |
work_keys_str_mv |
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