Microsatellite Instability in Young Women with Endometrioid type Endometrial Cancer
"nBackground: This study was designed to determine the frequency of Microsatellite Instability (MSI) in young Iranian pa­tients with endometrial carcinoma and to evaluate its association with histopathologic and clinical features of disease."nMethods: Microsatellite sta...
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2009-09-01
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doaj-73c7b28c349e40e7b2cf3bca608d82122020-12-02T10:01:29ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852009-09-013832430Microsatellite Instability in Young Women with Endometrioid type Endometrial CancerMR AbbaszadeganH Asadzadeh AghdayiF RastinE DadkhahM LotfalizadehN Mohamadian RoshanM FarzadniaA VelayatiA A'rabi"nBackground: This study was designed to determine the frequency of Microsatellite Instability (MSI) in young Iranian pa­tients with endometrial carcinoma and to evaluate its association with histopathologic and clinical features of disease."nMethods: Microsatellite status was analyzed in 23 patients with endometrioid type endometrial cancer who were less than 55 years. Clinicopathologic characteristics such as age, International Federation of Gynecology and Obstetric (FIGO) grad­ing and staging of tumor, family history of Hereditary Non-polyposis Colorectal Cancer (HNPCC), oral conception (OC) consump­tion, number of pregnancies, fertility, menstrual cycles and underlying disease were considered. Chi-square and Fisher exact tests were used to find the significant relationships."nResults: MSI analysis showed 8 patients (34.8%) were MSS (Microsatellite Stable), 15 patients (62.5%) were MSI positive. Among cases with MSI phenotype, 4 cases (17.4%) had low instability (MSI-L) and 11 cases (47.8%) had high instability (MSI-H). Three cases with MSI-H had family history of HNPCC related cancers. Five cases (21.7%) had infertility in which 4 of them (80%) had MSI phenotype. There was no statistically significant relationship between MSI phenotype and tumor grade and stage."nConclusion: Few studies reported high frequency of MSI among young patients. Some studies mentioned similar results in endo­metrioid type of tumor. This study showed even higher frequency (65%) when MSI analyzed in young endometrioid type endometrial patients. Most cases with infertility had MSI-H phenotype. It may suggest that beside women with family his­tory of HNPCC, EC screening using MSI would be beneficial in infertile women too.  http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/14147.pdf&manuscript_id=14147Microsatellite instabilityEndometrial CancerYoung patientsEndometrioidIran |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
MR Abbaszadegan H Asadzadeh Aghdayi F Rastin E Dadkhah M Lotfalizadeh N Mohamadian Roshan M Farzadnia A Velayati A A'rabi |
spellingShingle |
MR Abbaszadegan H Asadzadeh Aghdayi F Rastin E Dadkhah M Lotfalizadeh N Mohamadian Roshan M Farzadnia A Velayati A A'rabi Microsatellite Instability in Young Women with Endometrioid type Endometrial Cancer Iranian Journal of Public Health Microsatellite instability Endometrial Cancer Young patients Endometrioid Iran |
author_facet |
MR Abbaszadegan H Asadzadeh Aghdayi F Rastin E Dadkhah M Lotfalizadeh N Mohamadian Roshan M Farzadnia A Velayati A A'rabi |
author_sort |
MR Abbaszadegan |
title |
Microsatellite Instability in Young Women with Endometrioid type Endometrial Cancer |
title_short |
Microsatellite Instability in Young Women with Endometrioid type Endometrial Cancer |
title_full |
Microsatellite Instability in Young Women with Endometrioid type Endometrial Cancer |
title_fullStr |
Microsatellite Instability in Young Women with Endometrioid type Endometrial Cancer |
title_full_unstemmed |
Microsatellite Instability in Young Women with Endometrioid type Endometrial Cancer |
title_sort |
microsatellite instability in young women with endometrioid type endometrial cancer |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Public Health |
issn |
2251-6085 |
publishDate |
2009-09-01 |
description |
"nBackground: This study was designed to determine the frequency of Microsatellite Instability (MSI) in young Iranian pa­tients with endometrial carcinoma and to evaluate its association with histopathologic and clinical features of disease."nMethods: Microsatellite status was analyzed in 23 patients with endometrioid type endometrial cancer who were less than 55 years. Clinicopathologic characteristics such as age, International Federation of Gynecology and Obstetric (FIGO) grad­ing and staging of tumor, family history of Hereditary Non-polyposis Colorectal Cancer (HNPCC), oral conception (OC) consump­tion, number of pregnancies, fertility, menstrual cycles and underlying disease were considered. Chi-square and Fisher exact tests were used to find the significant relationships."nResults: MSI analysis showed 8 patients (34.8%) were MSS (Microsatellite Stable), 15 patients (62.5%) were MSI positive. Among cases with MSI phenotype, 4 cases (17.4%) had low instability (MSI-L) and 11 cases (47.8%) had high instability (MSI-H). Three cases with MSI-H had family history of HNPCC related cancers. Five cases (21.7%) had infertility in which 4 of them (80%) had MSI phenotype. There was no statistically significant relationship between MSI phenotype and tumor grade and stage."nConclusion: Few studies reported high frequency of MSI among young patients. Some studies mentioned similar results in endo­metrioid type of tumor. This study showed even higher frequency (65%) when MSI analyzed in young endometrioid type endometrial patients. Most cases with infertility had MSI-H phenotype. It may suggest that beside women with family his­tory of HNPCC, EC screening using MSI would be beneficial in infertile women too.   |
topic |
Microsatellite instability Endometrial Cancer Young patients Endometrioid Iran |
url |
http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/14147.pdf&manuscript_id=14147 |
work_keys_str_mv |
AT mrabbaszadegan microsatelliteinstabilityinyoungwomenwithendometrioidtypeendometrialcancer AT hasadzadehaghdayi microsatelliteinstabilityinyoungwomenwithendometrioidtypeendometrialcancer AT frastin microsatelliteinstabilityinyoungwomenwithendometrioidtypeendometrialcancer AT edadkhah microsatelliteinstabilityinyoungwomenwithendometrioidtypeendometrialcancer AT mlotfalizadeh microsatelliteinstabilityinyoungwomenwithendometrioidtypeendometrialcancer AT nmohamadianroshan microsatelliteinstabilityinyoungwomenwithendometrioidtypeendometrialcancer AT mfarzadnia microsatelliteinstabilityinyoungwomenwithendometrioidtypeendometrialcancer AT avelayati microsatelliteinstabilityinyoungwomenwithendometrioidtypeendometrialcancer AT aaaposrabi microsatelliteinstabilityinyoungwomenwithendometrioidtypeendometrialcancer |
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