SARS-CoV-2 is localized in cardiomyocytes: a postmortem biopsy case

SARS-CoV-2 is localized in cardiomyocytes: a postmortem biopsy case

A 72-year-old patient was admitted to the intensive care unit due to acute respiratory distress syndrome caused by COVID-19. On day 20, the patient experienced shock. The electrocardiogram showed ST segment elevation in leads V3–V6 and severe left ventricular dysfunction with an ejection fraction of...

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Main Authors: Yoshihiko Nakamura, Harutaka Katano, Noriko Nakajima, Yuko Sato, Tadaki Suzuki, Tsuyoshi Sekizuka, Makoto Kuroda, Yoshito Izutani, Shinichi Morimoto, Junichi Maruyama, Megumi Koie, Taisuke Kitamura, Hiroyasu Ishikura
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:International Journal of Infectious Diseases
Subjects:
SARS-CoV-2
immunostaining
cardiomyocyte
co-localization
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971221006470
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spelling doaj-73d9d82f85244404981a11772100b15d2021-10-03T04:38:29ZengElsevierInternational Journal of Infectious Diseases1201-97122021-10-011114346SARS-CoV-2 is localized in cardiomyocytes: a postmortem biopsy caseYoshihiko Nakamura0Harutaka Katano1Noriko Nakajima2Yuko Sato3Tadaki Suzuki4Tsuyoshi Sekizuka5Makoto Kuroda6Yoshito Izutani7Shinichi Morimoto8Junichi Maruyama9Megumi Koie10Taisuke Kitamura11Hiroyasu Ishikura12Department of Emergency and Critical Care Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan; Corresponding Author: Yoshihiko Nakamura, MD. PhD, Department of Emergency and Critical Care Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan; telephone: +81-92-801-1011 fax: +81-92-862-8330.Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, JapanDepartment of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, JapanDepartment of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, JapanDepartment of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, JapanPathogen Genomics Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, JapanPathogen Genomics Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, JapanDepartment of Emergency and Critical Care Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, JapanDepartment of Emergency and Critical Care Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, JapanDepartment of Emergency and Critical Care Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, JapanDepartment of Emergency and Critical Care Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, JapanDepartment of Emergency and Critical Care Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, JapanDepartment of Emergency and Critical Care Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, JapanA 72-year-old patient was admitted to the intensive care unit due to acute respiratory distress syndrome caused by COVID-19. On day 20, the patient experienced shock. The electrocardiogram showed ST segment elevation in leads V3–V6 and severe left ventricular dysfunction with an ejection fraction of 35%–40%. The left ventricle showed basal hypokinesis and apical akinesis, while the creatine kinase level was normal, indicating Takotsubo cardiomyopathy. On day 24, the patient died of multiple organ failure. In post-mortem biopsy, SARS-CoV-2 antigen was detected in cardiomyocytes by immunostaining. Moreover, SARS-CoV-2 RNA was detected in heart tissue. We need to further analyse the direct link between SARS-CoV-2 and cardiomyocytes.http://www.sciencedirect.com/science/article/pii/S1201971221006470SARS-CoV-2immunostainingcardiomyocyteco-localization
collection DOAJ
language English
format Article
sources DOAJ
author Yoshihiko Nakamura
Harutaka Katano
Noriko Nakajima
Yuko Sato
Tadaki Suzuki
Tsuyoshi Sekizuka
Makoto Kuroda
Yoshito Izutani
Shinichi Morimoto
Junichi Maruyama
Megumi Koie
Taisuke Kitamura
Hiroyasu Ishikura
spellingShingle Yoshihiko Nakamura
Harutaka Katano
Noriko Nakajima
Yuko Sato
Tadaki Suzuki
Tsuyoshi Sekizuka
Makoto Kuroda
Yoshito Izutani
Shinichi Morimoto
Junichi Maruyama
Megumi Koie
Taisuke Kitamura
Hiroyasu Ishikura
SARS-CoV-2 is localized in cardiomyocytes: a postmortem biopsy case
International Journal of Infectious Diseases
SARS-CoV-2
immunostaining
cardiomyocyte
co-localization
author_facet Yoshihiko Nakamura
Harutaka Katano
Noriko Nakajima
Yuko Sato
Tadaki Suzuki
Tsuyoshi Sekizuka
Makoto Kuroda
Yoshito Izutani
Shinichi Morimoto
Junichi Maruyama
Megumi Koie
Taisuke Kitamura
Hiroyasu Ishikura
author_sort Yoshihiko Nakamura
title SARS-CoV-2 is localized in cardiomyocytes: a postmortem biopsy case
title_short SARS-CoV-2 is localized in cardiomyocytes: a postmortem biopsy case
title_full SARS-CoV-2 is localized in cardiomyocytes: a postmortem biopsy case
title_fullStr SARS-CoV-2 is localized in cardiomyocytes: a postmortem biopsy case
title_full_unstemmed SARS-CoV-2 is localized in cardiomyocytes: a postmortem biopsy case
title_sort sars-cov-2 is localized in cardiomyocytes: a postmortem biopsy case
publisher Elsevier
series International Journal of Infectious Diseases
issn 1201-9712
publishDate 2021-10-01
description A 72-year-old patient was admitted to the intensive care unit due to acute respiratory distress syndrome caused by COVID-19. On day 20, the patient experienced shock. The electrocardiogram showed ST segment elevation in leads V3–V6 and severe left ventricular dysfunction with an ejection fraction of 35%–40%. The left ventricle showed basal hypokinesis and apical akinesis, while the creatine kinase level was normal, indicating Takotsubo cardiomyopathy. On day 24, the patient died of multiple organ failure. In post-mortem biopsy, SARS-CoV-2 antigen was detected in cardiomyocytes by immunostaining. Moreover, SARS-CoV-2 RNA was detected in heart tissue. We need to further analyse the direct link between SARS-CoV-2 and cardiomyocytes.
topic SARS-CoV-2
immunostaining
cardiomyocyte
co-localization
url http://www.sciencedirect.com/science/article/pii/S1201971221006470
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