The Coexistence of Generalized and Lateralized Periodic Discharges: Report of Two Adult Cases with SSPE and MELAS Syndrome
Generalized and lateralized periodic discharges have not been reported previously in the same EEG simultaneously. Here, we report two adult patients who suffered from rare clinical conditions [subacute sclerosing panencephalitis (SSPE) and nitochondrial myopathy, encephalopathy, lactic acidosis, and...
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Galenos Yayinevi
2011-09-01
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doaj-73dd619823634f2cb67f22a2dcf9911a2021-09-02T15:19:39ZengGalenos YayineviTürk Nöroloji Dergisi1301-062X1309-25452011-09-01173161166The Coexistence of Generalized and Lateralized Periodic Discharges: Report of Two Adult Cases with SSPE and MELAS SyndromeAslıhan Taşkıran0Serap Saygı1Department Of Neurology, Hacettepe University School Of Medicine, Ankara, TurkeyDepartment Of Neurology, Hacettepe University School Of Medicine, Ankara, TurkeyGeneralized and lateralized periodic discharges have not been reported previously in the same EEG simultaneously. Here, we report two adult patients who suffered from rare clinical conditions [subacute sclerosing panencephalitis (SSPE) and nitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome]. Their EEGs showed the same pattern consisting of generalized periodic discharges and lateralized periodic discharges in the same EEG simultaneously. Although the appearances of the EEG were very similar, discharges became more prominent after intravenous diazepam injection in the case with SSPE but were suppressed in the case with MELAS. Lesions in the magnetic resonance imaging (MRI) were located posteriorly in both patients, involving mainly subcortical white matter in the case with SSPE, but mainly the cortical area in the case with MELAS. Generalized periodic discharges are also reported in MELAS for the first time. The underlying mechanisms of the genesis of periodic discharges are still not known, and these two patients may help us to learn more about these rare patternshttp://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-71463Electroencephalographysubacute sclerosing panencephalitisMELAS syndrome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aslıhan Taşkıran Serap Saygı |
spellingShingle |
Aslıhan Taşkıran Serap Saygı The Coexistence of Generalized and Lateralized Periodic Discharges: Report of Two Adult Cases with SSPE and MELAS Syndrome Türk Nöroloji Dergisi Electroencephalography subacute sclerosing panencephalitis MELAS syndrome |
author_facet |
Aslıhan Taşkıran Serap Saygı |
author_sort |
Aslıhan Taşkıran |
title |
The Coexistence of Generalized and Lateralized Periodic Discharges: Report of Two Adult Cases with SSPE and MELAS Syndrome |
title_short |
The Coexistence of Generalized and Lateralized Periodic Discharges: Report of Two Adult Cases with SSPE and MELAS Syndrome |
title_full |
The Coexistence of Generalized and Lateralized Periodic Discharges: Report of Two Adult Cases with SSPE and MELAS Syndrome |
title_fullStr |
The Coexistence of Generalized and Lateralized Periodic Discharges: Report of Two Adult Cases with SSPE and MELAS Syndrome |
title_full_unstemmed |
The Coexistence of Generalized and Lateralized Periodic Discharges: Report of Two Adult Cases with SSPE and MELAS Syndrome |
title_sort |
coexistence of generalized and lateralized periodic discharges: report of two adult cases with sspe and melas syndrome |
publisher |
Galenos Yayinevi |
series |
Türk Nöroloji Dergisi |
issn |
1301-062X 1309-2545 |
publishDate |
2011-09-01 |
description |
Generalized and lateralized periodic discharges have not been reported previously in the same EEG simultaneously. Here, we report two adult patients who suffered from rare clinical conditions [subacute sclerosing panencephalitis (SSPE) and nitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome]. Their EEGs showed the same pattern consisting of generalized periodic discharges and lateralized periodic discharges in the same EEG simultaneously. Although the appearances of the EEG were very similar, discharges became more prominent after intravenous diazepam injection in the case with SSPE but were suppressed in the case with MELAS. Lesions in the magnetic resonance imaging (MRI) were located posteriorly in both patients, involving mainly subcortical white matter in the case with SSPE, but mainly the cortical area in the case with MELAS. Generalized periodic discharges are also reported in MELAS for the first time. The underlying mechanisms of the genesis of periodic discharges are still not known, and these two patients may help us to learn more about these rare patterns |
topic |
Electroencephalography subacute sclerosing panencephalitis MELAS syndrome |
url |
http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-71463 |
work_keys_str_mv |
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