Circulating Muscle-specific miRNAs in Duchenne Muscular Dystrophy Patients
Noninvasive biomarkers with diagnostic value and prognostic applications have long been desired to replace muscle biopsy for Duchenne muscular dystrophy (DMD) patients. Growing evidence indicates that circulating microRNAs are biomarkers to assess pathophysiological status. Here, we show that the se...
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doaj-73e7870b8f344e66af2b5cdb6780e7ed2020-11-25T00:04:03ZengElsevierMolecular Therapy: Nucleic Acids2162-25312014-01-013C10.1038/mtna.2014.29Circulating Muscle-specific miRNAs in Duchenne Muscular Dystrophy PatientsXihua Li0Yuying Li1Lei Zhao2Duo Zhang3Xuan Yao4Huihui Zhang5Yu-cheng Wang6Xin-yi Wang7Hongfeng Xia8Jun Yan9Hao Ying10Department of Neuromuscular Disease, Children's Hospital of Fudan University, Shanghai, ChinaKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, ChinaDepartment of Neuromuscular Disease, Children's Hospital of Fudan University, Shanghai, ChinaKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, ChinaKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, ChinaKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, ChinaClinical Research Center of Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, ChinaDepartment of Nutrition, Shanghai Xuhui Central Hospital, Shanghai, ChinaKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, ChinaModel Animal Research Center, and MOE Key Laboratory of Model Animals for Disease Study, Nanjing University, Nanjing, ChinaKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, ChinaNoninvasive biomarkers with diagnostic value and prognostic applications have long been desired to replace muscle biopsy for Duchenne muscular dystrophy (DMD) patients. Growing evidence indicates that circulating microRNAs are biomarkers to assess pathophysiological status. Here, we show that the serum levels of six muscle-specific miRNAs (miR-1/206/133/499/208a/208b, also known as myomiRs) were all elevated in DMD patients (P < 0.01). The receiver operating characteristic curves of circulating miR-206, miR-499, miR-208b, and miR-133 levels reflected strong separation between Becker's muscular dystrophy (BMD) and DMD patients (P < 0.05). miR-206, miR-499, and miR-208b levels were positively correlated with both age and type IIc muscle fiber content in DMD patients (2–6 years), indicating that they might represent the stage of disease as well as the process of regeneration. miR-499 and miR-208b levels were correlated with slow and fast fiber content and might reflect the ratio of slow to fast fibers in DMD patient (>6 years). Fibroblast growth factor, transforming growth factor-β, and tumor necrosis factor-α could affect the secretion of myomiRs, suggesting that circulating myomiRs might reflect the effects of cytokines and growth factors on degenerating and regenerating muscles. Collectively, our data indicated that circulating myomiRs could serve as promising biomarkers for DMD diagnosis and disease progression.http://www.sciencedirect.com/science/article/pii/S2162253116303171biomarkersDuchenne muscular dystrophysecretionserum miRNAs |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xihua Li Yuying Li Lei Zhao Duo Zhang Xuan Yao Huihui Zhang Yu-cheng Wang Xin-yi Wang Hongfeng Xia Jun Yan Hao Ying |
spellingShingle |
Xihua Li Yuying Li Lei Zhao Duo Zhang Xuan Yao Huihui Zhang Yu-cheng Wang Xin-yi Wang Hongfeng Xia Jun Yan Hao Ying Circulating Muscle-specific miRNAs in Duchenne Muscular Dystrophy Patients Molecular Therapy: Nucleic Acids biomarkers Duchenne muscular dystrophy secretion serum miRNAs |
author_facet |
Xihua Li Yuying Li Lei Zhao Duo Zhang Xuan Yao Huihui Zhang Yu-cheng Wang Xin-yi Wang Hongfeng Xia Jun Yan Hao Ying |
author_sort |
Xihua Li |
title |
Circulating Muscle-specific miRNAs in Duchenne Muscular Dystrophy Patients |
title_short |
Circulating Muscle-specific miRNAs in Duchenne Muscular Dystrophy Patients |
title_full |
Circulating Muscle-specific miRNAs in Duchenne Muscular Dystrophy Patients |
title_fullStr |
Circulating Muscle-specific miRNAs in Duchenne Muscular Dystrophy Patients |
title_full_unstemmed |
Circulating Muscle-specific miRNAs in Duchenne Muscular Dystrophy Patients |
title_sort |
circulating muscle-specific mirnas in duchenne muscular dystrophy patients |
publisher |
Elsevier |
series |
Molecular Therapy: Nucleic Acids |
issn |
2162-2531 |
publishDate |
2014-01-01 |
description |
Noninvasive biomarkers with diagnostic value and prognostic applications have long been desired to replace muscle biopsy for Duchenne muscular dystrophy (DMD) patients. Growing evidence indicates that circulating microRNAs are biomarkers to assess pathophysiological status. Here, we show that the serum levels of six muscle-specific miRNAs (miR-1/206/133/499/208a/208b, also known as myomiRs) were all elevated in DMD patients (P < 0.01). The receiver operating characteristic curves of circulating miR-206, miR-499, miR-208b, and miR-133 levels reflected strong separation between Becker's muscular dystrophy (BMD) and DMD patients (P < 0.05). miR-206, miR-499, and miR-208b levels were positively correlated with both age and type IIc muscle fiber content in DMD patients (2–6 years), indicating that they might represent the stage of disease as well as the process of regeneration. miR-499 and miR-208b levels were correlated with slow and fast fiber content and might reflect the ratio of slow to fast fibers in DMD patient (>6 years). Fibroblast growth factor, transforming growth factor-β, and tumor necrosis factor-α could affect the secretion of myomiRs, suggesting that circulating myomiRs might reflect the effects of cytokines and growth factors on degenerating and regenerating muscles. Collectively, our data indicated that circulating myomiRs could serve as promising biomarkers for DMD diagnosis and disease progression. |
topic |
biomarkers Duchenne muscular dystrophy secretion serum miRNAs |
url |
http://www.sciencedirect.com/science/article/pii/S2162253116303171 |
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