An Algorithm to Identify Target-Selective Ligands - A Case Study of 5-HT7/5-HT1A Receptor Selectivity.
A computational procedure to search for selective ligands for structurally related protein targets was developed and verified for serotonergic 5-HT7/5-HT1A receptor ligands. Starting from a set of compounds with annotated activity at both targets (grouped into four classes according to their activit...
Main Authors: | Rafał Kurczab, Vittorio Canale, Paweł Zajdel, Andrzej J Bojarski |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4896471?pdf=render |
Similar Items
-
Structural determinants influencing halogen bonding: a case study on azinesulfonamide analogs of aripiprazole as 5-HT1A, 5-HT7, and D2 receptor ligands
by: Krzysztof Marciniec, et al.
Published: (2018-05-01) -
Synthesis of Selective 5-HT6 and 5-HT7 Receptor Antagonists
by: Raux, Elizabeth A
Published: (2010) -
Synthesis of Selective 5-HT6 and 5-HT7 Receptor Antagonists
by: Raux, Elizabeth A
Published: (2010) -
Fingerprint-Based Machine Learning Approach to Identify Potent and Selective 5-HT2BR Ligands
by: Krzysztof Rataj, et al.
Published: (2018-05-01) -
Synthesis of Selective 5-HT7 Receptor Antagonists
by: Ehalt, Adam
Published: (2011)