Biogenesis of influenza a virus hemagglutinin cross-protective stem epitopes.
Antigenic variation in the globular domain of influenza A virus (IAV) hemagglutinin (HA) precludes effective immunity to this major human pathogen. Although the HA stem is highly conserved between influenza virus strains, HA stem-reactive antibodies (StRAbs) were long considered biologically inert....
Main Authors: | Javier G Magadán, Meghan O Altman, William L Ince, Heather D Hickman, James Stevens, Aaron Chevalier, David Baker, Patrick C Wilson, Rafi Ahmed, Jack R Bennink, Jonathan W Yewdell |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-06-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC4055778?pdf=render |
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