Oncogenic mutations of p110α isoform of PI 3-kinase upregulate its protein kinase activity.
In addition to lipid kinase activity, the class-I PI 3-kinases also function as protein kinases targeting regulatory autophosphorylation sites and exogenous substrates. The latter include a recently identified regulatory phosphorylation of the GM-CSF/IL-3 βc receptor contributing to survival of acut...
Main Authors: | Christina M Buchanan, James M J Dickson, Woo-Jeong Lee, Mark A Guthridge, Jackie D Kendall, Peter R Shepherd |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23936502/?tool=EBI |
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