Glutaredoxin catalysis requires two distinct glutathione interaction sites
Glutaredoxins have important roles in redox processes. Here the authors show that the enzymatic activity of glutaredoxins requires two distinct glutathione interactions sites, one recognizing the glutathione disulfide substrate and one activating glutathione as a reducing agent.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14835 |
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Article |
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doaj-740639bdf8af4d88af583ed4dd6926cd2021-05-11T07:51:27ZengNature Publishing GroupNature Communications2041-17232017-04-018111310.1038/ncomms14835Glutaredoxin catalysis requires two distinct glutathione interaction sitesPatricia Begas0Linda Liedgens1Anna Moseler2Andreas J. Meyer3Marcel Deponte4Department of Parasitology, Ruprecht-Karls UniversityDepartment of Parasitology, Ruprecht-Karls UniversityInstitute of Crop Science and Resource Conservation (INRES)-Chemical Signalling, University of BonnInstitute of Crop Science and Resource Conservation (INRES)-Chemical Signalling, University of BonnDepartment of Parasitology, Ruprecht-Karls UniversityGlutaredoxins have important roles in redox processes. Here the authors show that the enzymatic activity of glutaredoxins requires two distinct glutathione interactions sites, one recognizing the glutathione disulfide substrate and one activating glutathione as a reducing agent.https://doi.org/10.1038/ncomms14835 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Patricia Begas Linda Liedgens Anna Moseler Andreas J. Meyer Marcel Deponte |
| spellingShingle |
Patricia Begas Linda Liedgens Anna Moseler Andreas J. Meyer Marcel Deponte Glutaredoxin catalysis requires two distinct glutathione interaction sites Nature Communications |
| author_facet |
Patricia Begas Linda Liedgens Anna Moseler Andreas J. Meyer Marcel Deponte |
| author_sort |
Patricia Begas |
| title |
Glutaredoxin catalysis requires two distinct glutathione interaction sites |
| title_short |
Glutaredoxin catalysis requires two distinct glutathione interaction sites |
| title_full |
Glutaredoxin catalysis requires two distinct glutathione interaction sites |
| title_fullStr |
Glutaredoxin catalysis requires two distinct glutathione interaction sites |
| title_full_unstemmed |
Glutaredoxin catalysis requires two distinct glutathione interaction sites |
| title_sort |
glutaredoxin catalysis requires two distinct glutathione interaction sites |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-04-01 |
| description |
Glutaredoxins have important roles in redox processes. Here the authors show that the enzymatic activity of glutaredoxins requires two distinct glutathione interactions sites, one recognizing the glutathione disulfide substrate and one activating glutathione as a reducing agent. |
| url |
https://doi.org/10.1038/ncomms14835 |
| work_keys_str_mv |
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