Neuropsychological deficits in amyotrophic lateral sclerosis (ALS): a South India experience

• Main Authors: Jamuna Rajeswaran, Atchayaram Nalini
• Format: Article
• Language: English
• Published: LED Edizioni Universitarie 2013-04-01
• Series: Neuropsychological Trends
• Subjects: Cognitive function; Executive function; Neuropsychological assessment
• Online Access: http://www.ledonline.it/NeuropsychologicalTrends/allegati/NeuropsychologicalTrends_13_Rajeswaran.pdf

ALS is a terminal progressive degenerative neurological disorder studies suggest that approximately 35% to 52% of ALS patients experience cognitive deficits which may be identified early in the course of the disease. Cognitive deficits being the integral part of the disease has not been studied in the Indian setting. This is one of the first studies assessing the pattern of cognitive impairment in ALS in the Indian condition. The objective is to examine the neuropsychological profile of amyotrophic lateral sclerosis. Cognitive function was studied in 20 ALS patients: mean age 45.85±13.9 years (22-65). Neuropsychological test battery was administered. In all 21 test were administered individually in 4-5 sessions which lasted for 7-8 hours. The results show that the majority of patients were from lower/middle socio-economic background. Scores were compared with gender, age and education specific norms, wherein scores falling below 15th percentile of the normative data were treated as deficits. ALS-associated cognitive impairments include deficiencies in visual attention, working memory, fluency, cognitive flexibility, response inhibition, planning, problem solving, and visual-perceptual skills.These impairments indicate executive dysfunction. In conclusion ALS is a disease that affects higher cognitive frontal functions, especially the EF.